2025 Summer Intern – Investigative PK-ADME (iPK/ADME), Translational Pharmacokinetics and Pharmacodynamics - Development Sciences

Department Summary

This intern position is in the Translational Pharmacokinetics (PK) & Pharmacodynamic (PD) or tPKPD Department within Development Sciences. The tPKPD department applies preclinical models (in vitro, in vivo, and in silico) to determine the pharmacokinetics and/or pharmacodynamics of our biotherapeutics. The iPK/ADME Group focuses its effort on investigating the fate (disposition, biotransformation and distribution) and route of administration of novel biotherapeutic modalities, and effectively influence Drug Design, Delivery and Development Decision; we strive to develop and apply novel technologies through close and extensive collaborations and provide high-quality experimental data to help predict and translating the disposition of biological modalities from animals to humans. The information obtained from this work may be used to help select lead molecules, optimize dosing regimens or understand the PK behavior/metabolic fate of different molecular designs as we help advance molecules through stages of research and into early clinical development.

This internship position is located in South San Francisco, on-site.

The Opportunity

Design and implement in-vitro studies that are necessary to understand the biodistribution and fate of new modality candidates and predict their behavior in humans

Interpret data and communicate results in department meetings

Gain knowledge of PK concepts and acquire experience of technology applications in drug development

Work across disciplines with scientists in a variety of fields

Program Highlights

Intensive 12-weeks, full-time (40 hours per week) paid internship

Program start dates are in May/June (Summer)

A stipend, based on location, will be provided to help alleviate costs associated with the internship

Ownership of challenging and impactful business-critical projects

Work with some of the most talented people in the biotechnology industry

Who You Are

Candidate should be highly motivated individual with a passion for science, a curiosity to solve complex problems, attention to detail, as well as demonstrated effectiveness to work independently and in team settings.  The candidate should also be proficient in a broad variety of lab related technical skills (cell culturing, cell base assay, analytical chemistry, etc.).  You are expected to have a strong knowledge of basic pharmacology, drug metabolism and PKPD relationships.  An individual with strong communication and collaboration skills, along with the ability to clearly articulate solutions

Required Education

Must have attained a Bachelor's Degree (not currently enrolled in a graduate program)

Must be pursuing a Master's Degree (enrolled student)

Must have attained a Master's Degree

Must be pursuing a PhD (enrolled student)

Required Majors: Pharmacology, Pharmaceutical Science, Biomedical Engineering or related disciplines. 

Required Skills:

Experience of molecular biology assay (3D cell culturing, confocal microscopy etc.), and laboratory skills.

Experience with antibodies analytical methods (including HPLC, Western, etc) is preferred.

Ability to read and accurately summarize scientific literature.

Preferred Knowledge, Skills, and Qualifications

Excellent communication, collaboration, and interpersonal skills.

Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.

Understanding of PK concepts and the use of novel drug delivery system is preferred.

Experience with immunohistochemistry, immunofluorescence is nice to have.

Previous experience in labeling chemistry, especially with working with radioisotope, is a plus.

Relocation benefits are not available for this job posting. 

The expected salary range for this position based on the primary location of  California is $25-$45 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

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