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Job Description

The DMPK&M Neuroscience modeling group develops mathematical models (such as PKPD and QSP) of disease progression and drug response to inform preclinical drug optimization, guide study design, and provide human dose predictions. We take in vitro data, animal data, and when available, natural history and clinical data to translate preclinical findings into predicted clinical responses. We work closely with bench scientists and clinical scientists to provide high quality support in early drug research and development.

Job Description:

This summer internship project involves developing mechanistic models to link pathological nucleotide expansion repeat dynamics to neurodegeneration and related biomarkers, building on existing models and data.

As an intern, you will:

Calibrate and evaluate the ability of these models to describe disease progressionSimulate interventions to investigate potential therapeutic benefit and biomarker responsesPresent your findings to teams within Takeda including modelers and neuroscience colleagues.

A successful intern will provide our neuroscience teams quantitative comparisons of how our intervention(s) may work depending on patient characteristics and timing of intervention, leading to higher quality human dose prediction strategy within DMPK&M.

Internship Development Opportunities:

Exposure to how modeling and simulation can play a role in drug development in the preclinical and translational setting.Learn to understand different ways of working in the neuroscience modeling field.'Customer' management (eg modeler and neuroscience colleagues)

Job Requirements:

This position will be Hybrid and require 2-3 days in the Cambridge office per week.Must be a PhD candidate in Biomedical/Chemical Engineering, Applied Mathematics, or other discipline bridging mathematical modeling and biological systems.Prior experience with ODE-based mathematical modeling is required at a minimum.You must be able to build models in a programming language (e.g. MATLAB) and be able to communicate results to both modelers and non-modelers.Highly reliable and a strong team playerFlexible with an attention to detailStrong verbal and written communication skills

Internship Eligibility

Must be authorized to work in the U.S. on a permanent basis without requiring sponsorshipMust be currently enrolled in a degree program graduating December 2025 or laterThe internship program is 10-12 weeks depending on the two start dates (June 2nd- August 29th) or (June 16th - August 22nd)The intern must be able to commit to one of these time framesAble to work full time 40 hours a week during internship datesTakeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program

 Program Highlights:

Hands-on experience with real projects and responsibilitiesDedicated mentorship program pairing interns with experienced professionalsNetworking opportunities with industry professionals and fellow internsInternship events focused on professional and skills developmentExposure to multiple business areas or departments within a Pharmaceutical Organization

Applications will be accepted between December 18th and January 10th

Takeda Compensation and Benefits Summary 

We understand compensation may be an important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Hourly Wage Range:

$21.00 - $46.00

The estimated hourly range reflects an anticipated range for this position. The actual hourly wage offered will depend on the candidate’s school year/level to be entered following completion of internship.  The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location. 

 

U.S. internship benefits vary by location and may include: 

 Paid sick time 

Civic Duty paid time off 

Participation at company volunteer events  

Participation at company sponsored special events  

Access to on-site fitness center (where available) 

Commuter Benefit: To offset your work-commute expenses, Takeda provides U.S. employees with a fixed monthly subsidy to be used for either public transportation (transit) or parking.  

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypePaid Intern (Fixed Term) (Trainee)

Time TypeFull time

Job Exempt

No