By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. **Job Description** The DMPK&M Neuroscience modeling group develops mathematical models (such as PKPD and QSP) of disease progression and drug response to inform preclinical drug optimization, guide study design, and provide human dose predictions. We take in vitro data, animal data, and when available, natural history and clinical data to translate preclinical findings into predicted clinical responses. We work closely with bench scientists and clinical scientists to provide high quality support in early drug research and development. **Job Description:** This summer internship project involves developing mechanistic models to link pathological nucleotide expansion repeat dynamics to neurodegeneration and related biomarkers, building on existing models and data. As an intern, you will: + Calibrate and evaluate the ability of these models to describe disease progression + Simulate interventions to investigate potential therapeutic benefit and biomarker responses + Present your findings to teams within Takeda including modelers and neuroscience colleagues. A successful intern will provide our neuroscience teams quantitative comparisons of how our intervention(s) may work depending on patient characteristics and timing of intervention, leading to higher quality human dose prediction strategy within DMPK&M. **Internship Development Opportunities:** + Exposure to how modeling and simulation can play a role in drug development in the preclinical and translational setting. + Learn to understand different ways of working in the neuroscience modeling field. + 'Customer' management (eg modeler and neuroscience colleagues) **Job Requirements:** + This position will be Hybrid and require 2-3 days in the Cambridge office per week. + Must be a PhD candidate in Biomedical/Chemical Engineering, Applied Mathematics, or other discipline bridging mathematical modeling and biological systems. + Prior experience with ODE-based mathematical modeling is required at a minimum. + You must be able to build models in a programming language (e.g. MATLAB) and be able to communicate results to both modelers and non-modelers. + Highly reliable and a strong team player + Flexible with an attention to detail + Strong verbal and written communication skills **Internship Eligibility** + Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship + Must be currently enrolled in a degree program graduating December 2025 or later + The internship program is 10-12 weeks depending on the two start dates (June 2nd- August 29th) or (June 16th - August 22nd) + The intern must be able to commit to one of these time frames + Able to work full time 40 hours a week during internship dates + Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program **Program Highlights:** + Hands-on experience with real projects and responsibilities + Dedicated mentorship program pairing interns with experienced professionals + Networking opportunities with industry professionals and fellow interns + Internship events focused on professional and skills development + Exposure to multiple business areas or departments within a Pharmaceutical Organization Applications will be accepted between December 18th and January 10th **Takeda Compensation and Benefits** **Summary** We understand compensation may be an important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. **For Location:** Boston, MA **U.S. Hourly Wage Range:** $21.00 - $46.00 The estimated hourly range reflects an anticipated range for this position. The actual hourly wage offered will depend on the candidate’s school year/level to be entered following completion of internship. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location. U.S. internship benefits vary by location and may include: + Paid sick time + Civic Duty paid time off + Participation at company volunteer events + Participation at company sponsored special events + Access to on-site fitness center (where available) + Commuter Benefit: To offset your work-commute expenses, Takeda provides U.S. employees with a fixed monthly subsidy to be used for either public transportation (transit) or parking. **EEO Statement** _Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law._ **Locations** Boston, MA **Worker Type** Employee **Worker Sub-Type** Paid Intern (Fixed Term) (Trainee) **Time Type** Full time **Job Exempt** No