**Req ID:** RQ188430 **Type of Requisition:** Regular **Clearance Level Must Be Able to Obtain:** None **Public Trust/Other Required:** NACI (T1) **Job Family:** Scientists **Skills:** Analytical Chemistry,Biology,Mass Spectrometry (MS) **Experience:** 2 + years of related experience **US Citizenship Required:** Yes **Job Description:** **GDIT is seeking a Analytical Chemist with** **strong expertise in mass spectrometry** **to support the Walter Reed Army institute of Research’s Experimental Therapeutics Branch. This position will support the research, and any activities needed to most efficiently advance lead candidate drugs to the next level of testing and ultimately FDA approval.** **In this role, a typical day will include:** **Develop and validate analytical methods for the identification of candidate new drugs and putative metabolites using LC-MS/MS instruments including XL LTQ (Thermo Fisher l** **inear ion trap mass spectrometer** **and TQ-MS (Waters)** **tandem quadrupole mass spectrometer.** **Conduct in vitro and in vivo biological samples analysis using LC-MS/MS instruments, and process and collect raw data from mass spectrometry instruments.** **Conduct in vitro assays using TeCan Liquid Handling systems and Spectromax plate reader.** **Assist with the characterization of metabolites formation and metabolic profiles of candidate drugs using mass spectrometric analysis as needed.** **Conduct LC-MS/MS analysis for samples from liver microsomes and hepatocytes extract to assess for potential metabolism-based drug-drug interactions involving hepatic CYP450 enzymes.** **Conduct daily and weekly routine maintenance and troubleshoot for HPLC and mass spectrometry systems, a robotic liquid handling system (TeCan Auto sampler), and basic biology and pharmacology laboratory equipment.** **Prepare biological samples for analysis using methods to include tissue homogenization, blood spot filter puncture, and solvent extraction as needed.** **Conduct ELISA assays in support of pharmacokinetic and biomarker studies as needed.** **Perform chemical derivatization reactions when required for analyte detection.** **Assist in manual tasks including, but not limited to, filling liquid nitrogen dewars and tanks for use in laboratory operations, biohazard disposal, and acquisition/return of gas tanks from the logistics facility.** **Maintain appropriate data records and notebooks.** **Assist in chemical and supply inventories and laboratory organization as requested.** **Assist with the initiation and tracking of purchase request, and service calls through Medical Maintenance Branch.** **Comply with all specified guidelines regarding safety, security, standard operating procedures, written protocols, technical manuals, and procurement of supplies/equipment as per WRAIR regulations.** **Required:** **BS in Analytical Chemistry, Biology, or related field with relevant bioanalytical coursework** **2+ years of hands-on experience in analytical chemistry** **Working knowledge of HPLC analysis and familiarity with the handling of biological samples.** **Experience with Mass Spectrometry** **Experience with basic MS Office (or compatible) software for generating reports and summaries for presentations, managing data spreadsheets, requesting supplies and materiel as needed to perform general laboratory maintenance.** **Experience with metabolism related studies, along with troubleshooting and basic maintenance of mass spectrometry equipment.** **Excellent organizational and interpersonal skills as well as good written and oral communication.** **Must be a US citizen with the ability to obtain a favorable NACI T1 security investigation.** **Preferred:** **MS in Analytical Chemistry, Biology, or related field with relevant bioanalytical coursework with 2+ years of hands-on experience in analytical chemistry** **PhD in Pharmaceutical Sciences, Analytical Chemistry, Biology, or related field with relevant bioanalytical coursework with 1+ years of hands-on experience in analytical chemistry** **WHAT GDIT CAN OFFER YOU:** **401K with company match** **Customizable health benefits packages** **Internal mobility team dedicated to helping you own your career** **Challenging work that makes a real impact on the world around you** **Full-flex work week** **\#GDITHealth** **\#Militaryhealth** **\#MilitaryHealthGDITJobs** **\#GDITPRIORITY** The likely salary range for this position is $88,275 - $89,700. This is not, however, a guarantee of compensation or salary. Rather, salary will be set based on experience, geographic location and possibly contractual requirements and could fall outside of this range. Our benefits package for all US-based employees includes a variety of medical plan options, some with Health Savings Accounts, dental plan options, a vision plan, and a 401(k) plan offering the ability to contribute both pre and post-tax dollars up to the IRS annual limits and receive a company match. To encourage work/life balance, GDIT offers employees full flex work weeks where possible and a variety of paid time off plans, including vacation, sick and personal time, holidays, paid parental, military, bereavement and jury duty leave. To ensure our employees are able to protect their income, other offerings such as short and long-term disability benefits, life, accidental death and dismemberment, personal accident, critical illness and business travel and accident insurance are provided or available. We regularly review our Total Rewards package to ensure our offerings are competitive and reflect what our employees have told us they value most. We are GDIT. A global technology and professional services company that delivers consulting, technology and mission services to every major agency across the U.S. government, defense and intelligence community. Our 30,000 experts extract the power of technology to create immediate value and deliver solutions at the edge of innovation. We operate across 30 countries worldwide, offering leading capabilities in digital modernization, AI/ML, Cloud, Cyber and application development. Together with our clients, we strive to create a safer, smarter world by harnessing the power of deep expertise and advanced technology. We connect people with the most impactful client missions, creating an unparalleled work experience that allows them to see their impact every day. We create opportunities for our people to lead and learn simultaneously. From securing our nation’s most sensitive systems, to enabling digital transformation and cloud adoption, our people are the ones who make change real. GDIT is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status, or any other protected class.