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Organization Overview:

In Lilly Genetic Medicines, we are building state-of-the art expertise in major oligonucleotide-based therapeutics and delivery approaches, with an emphasis on innovative approaches with potential for breakthrough efficacy. Our agile and diverse team strives to operate as an autonomous ‘biotech-like’ company within the walls of Lilly. We are looking for an engaged and independent team member who will make impactful contributions to next-generation preclinical drug discovery efforts. Oligonucleotide laboratory chemists as well as experienced small molecule chemists with a desire to transition to oligonucleotide chemistry are encouraged to apply.

You will join our fast-paced, interdisciplinary team as we discover novel RNA/oligonucleotide-based medicines with disease-curing potential. The successful applicant will utilize their knowledge and technical expertise to complement and enable core capabilities and help drive the discovery and development of RNA-based clinical candidates. Do you have an aptitude for innovative applied chemistry towards drug discovery and a desire to use your skills to improve lives? We want you on our team!

Responsibilities:Synthesize, purify, and analyze highly modified oligonucleotides/conjugates and small molecules to drive projects forward efficientlyPrioritize and lead in proactive safety practices as a part of an effective laboratory cultureIndependently problem-solve in the laboratory setting to overcome synthetic challenges and improve upon existing workflowsMaintain a productive laboratory workspace including the operation and maintenance of an oligonucleotide synthesizer and/or other scientific equipmentCollaborate with chemists and scientists from other fields in a team environment focused on experimental execution and delivering on shared project goalsInterpret and communicate structure-activity relationships and generate new oligonucleotide-based designsSearch relevant chemical and scientific literature and implement new strategies and techniques accordinglyAccurately document experimental procedures and communicate results via presentations and written reports

Basic Qualifications:Bachelors or Master's degree in Chemistry or a related scientific field.

Additional Skills/Preferences:At least 1-2 years of experience in synthetic organic and/or oligonucleotide chemistry is highly preferred.Experience in solid-phase oligonucleotide synthesis using and trouble-shooting automated solid-phase synthesizers and optimizing synthetic protocols and reaction schemasExperience in small molecule organic synthesis including design of synthetic strategies, reaction optimization, work-up/purification techniques, and characterization (NMR, MS, etc.)Experience in the optimization of purification protocols for oligonucleotidesKnowledge or experience in the areas of bioconjugation chemistry as applied to peptides or oligonucleotidesExperience with analytical and physiochemical characterization of novel biomaterials (e.g., mass spectrometry, separation techniques and other biophysical/biochemical techniques)Excellent record keeping and communication skillsConfident, execution-focused, and team oriented with a desire to thrive in an entrepreneurial environment

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