Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position 

The Associate Manufacturing Scientist supports the production of drug substances and drug products. Their responsibility will focus on the preparation of solutions and reagents by following standard protocols. This technically focused position supports lab work, helps solve problems, and effectively communicates with colleagues.

Responsibilities 

Follow batch records, SOPs, and work instructions to detail Document all operations in batch records and notebooks Comply with GMP protocols Assist other chemists within the CMC group during synthesis and chromatography of oligonucleotides including: Reagent solution preparation Column Packing Mobile phase preparation Fraction collection Operate TFF to desalt purified RNA solutions Operate a lyophilizer and package solid drug substance Execute processes as part of a team to ensure production timelines are kept and quality product is produced Maintain a clean work space Maintain safety by wearing required personal protective equipment

Requirements: 

BS or MS in chemistry, biochemistry, engineering, or related scientific field Entry level to 3 years experience in a similar position Good verbal and written communication skills Ability to work in a team environment Ability to pay attention to detail

Preferred: 

Experience working in a GMP setting and controlled documentation

Wisconsin pay range $58,000—$68,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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