Protein Characterization Associate Scientist III will report to Director-level personnel in Assay Development to support Quality Control, Process Development, and other CMC departments. This role is responsible for building, optimizing, and maintaining chromatographic and biophysical assays in support of gene therapy product release and characterization. This role is expected to be at least 80% on site at our Redwood City location and at most 20% remote.What you'll do: Lead development, qualification, validation, and transfer of chromatographic and biophysical assays in some or all following categories: 1) Chromatography, including SEC, AEX, RP, and AF4 2) Light scattering applications, including DLS and MALS 3) Capillary electrophoresis, including CE-SDS, CE-LIF, and icIEF 4) Mass spectrometry applications, including intact LC-MS, peptide-mapping LC-MS/MS, and quantitative LC-MS/MS with MRM Lead conception, design, and execution of robustness testing Lead pilot forced degradation projectsLead transfer of processes, technology, and assays to/from internal and external labsOversee assay development, testing, and troubleshooting at internal and external labsEvaluate, implement, and optimize new technology within Assay Development to support product extended characterization Present results, conclusions, and implications to cross-functional teams and senior management to support data-driven decision makingParticipate in external scientific meetingsAuthor test procedures, standard test methods, SOPs, protocols, and technical reportsServe as a subject matter expert for chromatographic and biophysical assaysTrain and mentor junior personnel in technical areasMaintain a detailed awareness of industry regulatory guidance and standards for assay validation and performanceMaintain current knowledge of advancing technologies and propose their applications to ongoing projects. Maintain excellent documentation of laboratory activitiesPerform routine lab maintenanceOther responsibilities may be assigned as neededAbout you: Associate Scientist: Master’s degree with 8+ years or Bachelor’s degree with 10-12 years of relevant biotechnology industry experience.Experience in assay development is requiredAbility to read and extract information from published literature and internal reports is requiredExpertise is required in some or all of the following techniques: HPLC, AF4, CE, DLS, and MALS, LC-MS, and LC-MS/MSExperience in the qualification/validation of quantitative assays and knowledge of FDA requirements is strongly desiredBroad knowledge of protein, cell, or nucleic acid assay methods and biochemistry with application to gene therapy is strongly desiredExperience working with AAVs is a plus.Expertise in BLI, DSF, AUC, or BMI is desirable but not essential. Must be a self-starter, proactive, co-operative, and proficient at working both independently and in a small team environmentProven initiative and demonstrated accountability in a fast-paced environment with high degree of flexibilityDetail oriented and with time management skillsExcellent verbal and written communication skillsExperience in presenting data through written reports and oral presentation; publication in a peer-reviewed journal or presentation at a conference is desiredProficiency with Empower, Dynamics, Astra, and other common analytical software desiredProficient with MS Office and other common office software$121,000 - $138,000 a yearThe salary range for this position is $121,000 USD to $138,000 USD annually, with the opportunity to earn an annual bonus. This salary range is an estimate, and the actual salary may vary based on a candidate’s qualifications, including education, length of experience, location, and market data.  Employees in this position are eligible to participate in the applicable Company equity incentive award plan. The amount of incentive varies and is subject to the terms and conditions of the plan.  Employees in this position are eligible to participate in the Company’s standard employee benefit programs, which currently include the following: medical, dental, vision, 401k, STD/LTD, life and accident insurance, and either paid time off or flexible paid time off.About UsAdverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.
At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self.  We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation