Site Name: UK - Hertfordshire - Stevenage, USA - Massachusetts - Cambridge Posted Date: Dec 2 2024 The Department of Clinical Pharmacology Modelling and Simulation (CPMS) at GSK is recruiting for a Director level Quantitative Systems Pharmacologist, with a robust background in either Respiratory & Immunology or Infections Diseases or Vaccines. This position represents an excellent opportunity for professionals with a PhD, MD, PharmD or equivalent doctoral background, who are experienced mathematical modellers, where one will use Quantitative Systems Pharmacology, mathematical modelling, and computational skills together with Pharmacometrics to advance the vision and mission of GSK’s rapidly expanding portfolio. Sought after experiences for this position include building and integrating mechanistic mathematical models and disease platforms with advanced analytical techniques (such as machine learning) to enhance the robustness and quality of decision-making from exploratory research, clinical development, registration, and life cycle management. At GSK we develop therapies of various modalities for a broad range of indications. CPMS responsibilities and accountabilities commence at candidate selection stage with preparations of first time in human trials, and continue through to filing, registration, and market expansion. As a member of a global department with diverse expertise, you will enjoy a highly supportive environment for scientific innovation, business impact and professional growth. CPMS work directly supports GSK mission to help our patients feel better and live longer by getting ahead of disease together. Key Responsibilities: The responsibilities listed below outline the scope of the position. The application of these tasks may vary, based upon evolving business needs. Build, develop, guide development and/or utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities; conduct simulations to generate virtual patients to optimize trial design; conduct meta-analyses as appropriate to generate knowledge through data re-use. Develop and/or utilize state-of-the-art mathematical tools to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction. Contribute to clinical program design and dosing regimen selection, trial protocols, analysis plans, study reports and regulatory submissions as appropriate. Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms. Learn and apply emerging modelling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline. Present strategy and defend outcome of model-based approaches to internal governance boards and regulatory agencies. Promote Model-Informed Drug Discovery and Development (MID3) through external presentations at international conferences and publications in peer-reviewed scientific journals. Basic Qualifications PhD, MD, or PharmD with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and development. Substantial experience in utilizing mechanistic mathematical modelling and simulation (QSP, PKPD, etc.) to apply to questions in drug discovery and development to solve practical problems in industry and/or academia. Experience working with key stakeholders in a cross functional environment. Demonstrated aptitude for productive collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results. Passion for Quantitative Clinical Pharmacology and desire to innovate for better outcome. Strong track record of implementation of MIDD approaches to accelerate patient access to novel therapies. Strong publication record in peer-reviewed journals. Prior experience in clinical QSP modelling (especially, either in Respiratory & Immunology or Infections Diseases or Vaccines) in an industry setting. Preferred Qualifications A doctorate and a postdoc that are relevant to Quantitative Systems Pharmacology (e.g., Mathematics, Engineering, Physics, Systems Biology, Mathematical Modelling, etc.) is preferred but not required. Strong drive and learning agility to build knowledge on a drug-disease system, symptom progression, standard of care, and trial design. Clear evidence of ability to make sound judgement in complex situations and adapt to changing business needs by prioritizing multiple tasks. #LI-GSK* Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive . As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.