**HOW MIGHT YOU DEFY IMAGINATION?** At Amgen, every challenge is an opportunity. And every opportunity brings the potential to change lives. Our shared mission—to serve patients—has driven our status as one of the world’s preeminent biotechnology companies, reaching over 10 million patients worldwide. Leverage your high-level expertise to lead and forge partnerships that advance the biotechnical and biopharmaceutical science that can turn the tide of serious, life-interrupting illnesses. **Executive Director, Computational Translational Target Discovery** **Live** **What you will do** Let’s do this. Let’s change the world. In this vital role you will establish and lead the Computational Translational Target Discovery (CTTD) Group, a critical initiative at the forefront of our mission to transform patient outcomes. This high-impact role will integrate advanced genomic resources, cutting-edge translational insights from Amgen's clinical trials, and state-of-the-art computational biology to accelerate the discovery of high-value therapeutic targets. The successful candidate will build and lead a multidisciplinary team, driving innovation and cross-functional collaboration across R&D to shape Amgen’s pipeline and drive strategic priorities forward. Reporting into Precision Medicine, you will lead the CTTD team to deliver measurable impact on Amgen’s pipeline and innovation capabilities. **Responsibilities** Target Discovery Leadership: + Lead computational target discovery efforts to identify and validate high-value drug targets and actionable disease mechanisms. + Align target nomination processes with pipeline priorities, ensuring integration across Precision Medicine, Amgen Research Reykjavik, Discovery Therapeutic Areas, and cross-functional R&D teams. Clinical Data Integration and Utilization: + Leverage clinical datasets to deepen mechanistic understanding of existing targets and uncover novel therapeutic opportunities. + Lead the development of therapeutic hypotheses to effectively guide functional genomic validation, ensuring robust and actionable insights. Team Building and Collaboration: + Build and manage a high-performing team of computational biologists, coordinating efforts across a federated model. + Foster collaboration across R&D teams to streamline processes and enhance discovery efficiency. Strategic Impact: + Develop and execute a strategic roadmap for target discovery, accelerating the translation of early research into clinical applications. + Communicate the vision, goals, and outcomes of target discovery initiatives to internal and external stakeholders. + Drive execution of strategy cross-functionally to deliver measurable impact **Win** **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The candidate we seek is an experienced leader with the following qualifications. **Basic Qualifications:** + Doctorate degree & 6 years of biology research and computational biology experience OR + Master’s degree & 10 years of biology research and computational biology experience OR + Bachelor’s degree & 12 years of biology research and computational biology experience AND + 6 years of managerial experience directly managing people and/or leadership experience leading teams, systems-based innovations, programs **Preferred Qualifications:** + Proven leadership in genomics and computational biology with a track record of successful target discovery. + Strong problem-solving skills and adaptability in a dynamic R&D environment. + Demonstrated ability to lead cross-functional teams and foster collaboration. + Strategic thinker with a capacity for operational excellence and innovation. + Visionary leadership with a commitment to fostering a culture of collaboration and scientific excellence. + Exceptional communication skills to align and inspire teams across the organization. + Deep understanding of computational methods and their application in translational research. + Proven ability to synthesize complex data and communicate insights to both technical and non-technical audiences. + Experience building, mentoring, and leading high-performing teams. They will also embody the Amgen leadership attributes which are: + **Inspire:** Create a connected, inclusive, and inspiring work environment that empowers talent to thrive + **Accelerate:** Enable speed that matches the urgency of patient needs by encouraging progress over perfection + **Integrate:** Connect the dots to amplify the collective power of Amgen to drive results for patients, staff, and shareholders + **Adapt:** Lead through change by adapting to an ever-changing environment and defining a clear course of action to deliver results **Thrive** **What you can expect of us** As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. The annual base salary range for this opportunity in the U.S. is $271,118 - $322,291. In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: + Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans and bi-annual company-wide shutdowns + Flexible work models, including remote work arrangements, where possible **Amgen’s Commitment to Our Staff** At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our “people-first” philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business. We equip all our staff members to live well-rounded, healthy lives. Most recently, Amgen added benefits for transgender employees and continues to pride itself on industry-leading, family-friendly offerings for families of all compositions. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.