AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies. AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent.
Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy, and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.
Accountabilities
The Global Development Scientist Director is an important part of the Clinical Project Team (CPT) and Global Study Team (GST), working harmoniously and cross-functionally (in a matrix environment) with other CPT & GST members, Site Management & Monitoring (SMM), field-based liaisons, and site personnel. The Global Development Scientist Director and counterpart Global Development Medical Director work collaboratively in the clinical aspects underpinning a product.
This includes shared responsibility with Clinical Operations team members in the planning and execution, including recruitment and delivery of a clinical study. Accountabilities include clinical support for the development and implementation of early and/or late-phase AstraZeneca-sponsored clinical program strategies. As such, you will provide scientific input into the design & implementation of clinical trial(s), their delivery, clinical data review and data cleaning, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e., clinical input to NDA/BLA). The Global Development Scientist Director may also provide expert input or lead functional process improvement initiatives and provide contributions to cross-asset or cross-tumor area working groups depending on the level of experience.
This position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of stakeholders both within and external to AstraZeneca. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws, and adhere to Good Clinical Practice (GCP) and regulatory requirements.
What you'll do:
Work cross-functionally within CPT to ensure the clinical strategy is translated into the development of the study concept document, study protocol, and related documents.Provide clinical/scientific input into the design & implementation of clinical trial(s), their delivery, clinical data review and data cleaning, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e., clinical input to NDA/BLA).Establish key relationships internally with clinical project teams, and externally with regulatory bodies and external service providers.Accountable for the relevance and accuracy of clinical science underpinning clinical study based on detailed scientific review and consultation, for the clinical and scientific leadership and integrity of protocols and/or components of clinical plans, and for the delivery of final protocol and its governance approval.Lead the development of the protocol and related documents and the development and delivery of the clinical study report to meet GCP, ICH, and all AstraZeneca quality standards.Lead cross-functional projects to ensure the successful passage of drugs through all phases of the drug development process or contribute to one or more elements of such a project as a technical expert.Review and interpret medical data and clinical trial data and come up with conclusions with Medical Director.Support the development of clinical components of regulatory and EC/IRB submission documents for instances where marketing approval is warranted. Prepare and provide input to clinical study reports (CSRs) and clinical portions of Regulatory Documents (e.g., IB, DSUR, PSUR, regulatory responses).- Participate or lead as needed the review and assessment of new opportunities and ESRs.Responsible for timely responses to investigational study sites for local ICF changes, protocol & EC/IRB questions/requests.Contribute to development and delivery of face-to-face or virtual investigator and supervise training.Essential Skills/Experience
Bachelor of Science in Life Sciences or equivalent is requiredMinimum of 5 years of relevant experience; 3+ years’ experience Pharma Industry and/or CRO in drug development; 1 years' experience in Clinical Scientist role in Clinical DevelopmentOncology experience required (hematology-oncology experience preferred)Industry or Academic experience in drug development required with experience in malignant hematology clinical trials strongly preferred.Sufficient technical knowledge (haemato-oncology background preferred) to be able to interact with confidence with internal and external partnersPossesses sound foundational knowledge of FDA and other major country regulations and detailed knowledge of Good Clinical Practice other regulations governing clinical research.Possesses general knowledge of 1) medical monitoring 2) Regulatory approval process in relevant countries; 3) pharmaceutical industry/R&D operations; 4) marketing and commercial fundamentals.Drug Development/Clinical Development Planning: Demonstrates a consistent track record to both independently complete, and lead peers in completion in components of sophisticated plans, related documents, appropriate methodologies, measures, analytical plans, and evaluation tools.Ability to drive/contribute to protocol design, writing, and implementation
Preferred Skills/Experience
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace, and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Learn from our diverse team of the brightest minds as we seamlessly work together. It's where academia meets industry to share knowledge, grow together, and build meaningful careers.
Ready to make a difference? Apply now!
Date Posted
03-Mar-2025Closing Date
20-Mar-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.