The Oregon National Primate Research Center (ONPRC) is located 12 miles west of the OHSU main campus, and sits on 162 acres of land featuring forested areas, research and administration buildings, indoor and outdoor animal housing, a pond, and 2-mile perimeter walking path. Our mission is to improve human health and the quality of life through the support of nonhuman primate research programs that advance our knowledge of the causes, preventions, treatments, and cures of debilitating diseases.
To meet the challenge of supporting the exponential expansion in infectious disease (ID) research and the specialized expertise required to conduct ABSL-2+ and ABSL-3 infectious disease studies in NHPs, the ONPRC formed the Infectious Disease NHP Resource (IDR). The IDR is a dedicated group of highly trained veterinarians, technicians, and immunologists that provide specialized support to investigators conducting research of and related to infectious diseases. The IDR has principal responsibility for management, experimental conduct/compliance, and support of investigators utilizing nonhuman primates (NHP) assigned to experimental protocols. Specifically, the goals of the IDR are to: 1) aid investigators in performing high quality NHP ID research, including new investigators that may be transitioning from research focused on small animals or humans to NHPs; 2) promote optimal use of the animal resource and development/optimization of these unique models; 3) manage the AIDS Macaque Resource as a national resource; 4) provide expertise in managing NHPs used in infectious disease studies to ensure safety for personnel and study animals; 5) provide access to state-of-the-art immunological assays and analysis for studies in the NHP model; and 6) provide a management core for hosting NHP infectious disease studies for off-site and collaborating investigators. The IDR will continue to facilitate growth in critical areas such as immunology, pathogenesis of infectious diseases, development and optimization of therapeutics and vaccines, and in the priority area of further elucidating AIDS reservoirs and latency reversal leading to a functional cure. Continued development and provision of state-of-the-art immunological assays will enhance the IDR’s ability to host and provide immunologic support to collaborative projects at the local, regional, and national level.
Function/Duties of PositionThe IDR NHP Senior Research Project Manager is responsible for supervision, coordination and support of ongoing and newly funded infectious disease and related research studies using non-human primates for the ONPRC. Specifically, the person in this role is responsible for coordinating NHP research protocols with Principle Investigators from OHSU, ONPRC, VGTI and outside institutions. In conjunction with the IDR Director and ONPRC veterinary staff, the NHP Senior Research Project manager coordinates research protocols to ensure research specimens are collected, processed, and preserved in compliance with animal welfare regulations. As a Senior Research Project Manager in this position, there is an increased responsibility for managing IDR staff which includes: coordinating and/or performing training, scheduling IDR staff and protocol procedures, and coordinating animal sampling with other research investigators.
Additional duties include, but are not limited to:
Communicate directly with Principle Investigators from OHSU, ONPRC Divisions, and external institutions to coordinate research objectivesSignificantly contributes to grant proposalsAssist with and perform surgeries of non-human primates (including scheduling and administration of drugs)Collect and prepare blood samples including shipping and handling of animal tissues to various support laboratoriesInteract with the veterinary staff, animal care staff, surgical staff, and in some cases to facilitate social environmental enrichment of non-human primatesCollect, enter, and perform statistical analysis of data and reporting of research findings in written and oral formatsOperate CT scanner and interpret scan imagesPerform specialized techniques such as viral challenges, vaccine inoculations, intrabronchial administration of Mtb Provide oversight of DEA controlled substances, including proper recordkeeping and tracking of usageAssist with ordering and replenishment of supplies for laboratory and surgical procedures and maintain proper inventory to support IDR samplingPerform additional general lab support duties, including maintenance of laboratory supplies and equipment, autoclaving and disposing of wasteThe NHP Senior Research Project Manager has a responsibility to support research staff by assuring that their research program maintains compliance with various federal regulations regarding animal research activities by pre-reviewing animal research protocols for congruency with IACUC/IBC, working with the researchers and principal investigators to develop quality protocols, and implementing good practices for animal research.
Conduct the pre-reviews and when necessary, communicate inconsistencies with researchersEnsure congruency of protocols and submitted project schedules, regardless of fundingSchedule and coordinate compliant animal proceduresResearch, draft and maintain animal research policies that would ensure compliance by research investigatorsDevelop training documents and guidelines for training purposes Assist in development of standard operating proceduresParticipate in internal and external quality, laboratory, and vendor auditsAdditional responsibilities of the NHP Senior Research Project include, but are not limited to:
Develop, implement, and maintain appropriate Quality Assurance/Quality Control (QA/QC) proceduresAuthor and review technical documents (e.g., develop reports, SOPs, and technical reports)Actively participate in or lead the discussion of experiment results and project status, risks, and plans forwardEffectively generate and present experiment findings and project progress and results in various forms, ranging from concise spreadsheets to PowerPoint presentationsPerform various administrative tasks necessary for laboratory function (inventory management, equipment maintenance, etc.)Ensure adherence to all laboratory SOPs and troubleshoot issues in both experiments and routinely performed proceduresEnsure project documentation, including electronic records are sufficiently maintained to evaluate, trouble-shoot and reproduce experimental resultsProvide training and support to laboratory staff as needed, primarily during the implementation of new procedures or modifications based on assay optimization projectsMaintain cleanliness of work areas and keeps work areas organized and stockedResponsible for the knowledge and practice of safety SOPs in the laboratoryWears appropriate PPE as requiredComplete all required institutional and laboratory trainingsRequired Qualifications Master's in relevant field AND 5 years of relevant experience OREquivalent combination of Bachelor's in relevant field in conjunction with training and experience may be consideredMay require specific experience in particular area of researchMinimum of 5 years of laboratory experience in molecular/cellular biology, animal, and/or invivo researchAbility to communicate effectively, including use and meaning of scientific terminology in both written and oral formats Ability to work both independently and in a small group setting Working knowledge (18 months relevant work experience) of Microsoft Excel and WordDemonstrated independence and competence to perform data management and analysis of research findings, including use of spreadsheets, graphics and statistical programsAbility to interact in a positive and productive manner, and to work efficiently and skillfully with a variety of diverse staff Ability to prioritize work demands, and coordinate research protocols with other staff Organizational skills and careful attention to details to satisfactorily perform job duties requiring procedural steps to be consistent and completed fully and timely Detailed record-keeping, cataloging of samples, data entry and statistical analysis, laboratory maintenance, autoclaving and use of sterile techniques Preferred Qualifications Degree in Biology, Zoology, Animal sciences, Immunology or PathologyExperience with large primate studies, managing multiple research projects, and performing, analyzing and reporting results of immune assays5 years laboratory work experience performing immunoassays and cell separation techniques5 years’ experience in managing labs or research units, training and supervising of students and RA’sMaintaining inventories of laboratory supplies and equipmentExperience with geriatric or immune compromised and ABSL-3 with non-human primates Additional Details
WORKING CONDITIONS:
Work is performed in laboratory settings with potential risk of exposure to hazardous chemicals, materials, animals and equipment. Additionally, there is a risk of exposure to zoonotic agents by injury, by direct contact with animals or their tissues and body fluids, or by contact with equipment contaminated by animals or their tissues and body fluids in some work areas. Willingness to work in Biosafety Level 2 and 3 facilities.
PHYSICAL DEMANDS & EQUIPMENT USAGE:
Able to lift/move equipment weighing up to 50 lbs, working in a biosafety cabinet for long periods, physical dexterity to work in areas that may have slippery conditions and have an ability to minipulate existing animal housing. Ability to stand for 5 continuous hours at a time. Ability to work on a computer for 8 continuous hours a day. Able to perform the essential functions of the position with or without accommodation.
All are welcome Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.