Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 18 2024 GSK is looking for a highly motivated cell biologist with cellular imaging experience to join the department of Discovery Biology and Screening (DBS) at GSK’s research facility in Upper Providence, Pennsylvania. The primary responsibility of the DBS department is to deliver high quality, biologically relevant pre-clinical leads for all GSK therapeutic areas, by employing a combination of scientific tools and methodologies, including but not limited to assay development, high throughput screening, compound profiling, and mechanism of action studies. As an Investigator, you will apply your cell biology and imaging expertise to develop complex cell based assays for hepatology, respiratory and oncology programs for use in high-throughput screening and mechanistic studies. This is an exciting, lab-based role that will allow the individual to contribute to early drug discovery programs through validation of novel targets and new chemical entities. The successful candidate is expected to be effective in designing and executing experiments at the highest possible scientific standard, be highly flexible and productive, and possess positive communication skills. Key Responsibilities: Independently design, implement, analyze, and interpret high content fluorescent imaging assays to support multiparametric large-scale screening across multiple disease areas (oncology, hepatology & respiratory). Optimally derive information content from imaging readouts through internal collaboration with Data Science and AI/ML teams. Develop and troubleshoot disease relevant cellular assays using a wide range of technologies. Communicate experimental findings effectively, in written and verbal formats. Work collaboratively in a matrix team environment to drive timely delivery of projects and objectives. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD with 2-3 yrs experience or Master’s degree with 8-10 yrs experience in biological sciences (such as Cell Biology, Immunology, Oncology or Molecular Pharmacology). More than two years experience in confocal microscopy, high content imaging, and image analysis At least one year experience with cell biology, cell culture, and cell-based assay development. Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience running high throughput, high content screens (i.e. understanding of screening best practices, experience using automated liquid handling platforms). Expertise in one or more of the following techniques and data analysis: multicolor flow cytometry, primary cell isolation and culture, complex cellular systems,3D culture and phenotypic assays. Experience with standard image analytics, secondary analysis packages, and data visualization tools (i.e. Image J/FIJI, Columbus/Harmony, Spotfire, Genedata Screener, etc) to analyze imaging data. Ability to independently design, execute and interpret high-quality experiments. Previous experience in the pharmaceutical/biotech industry Strong communication skills; comfort presenting both virtually and in person. Proven track record of teamwork, adaptability, innovation, initiative, and integrity. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *This is a job description to aide in the job posting, but does not include all job evaluation details. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. 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