We are seeking outstanding, highly motivated, and creative candidates for a Scientist or Senior Scientist role in Dr. Jonathan Yen's lab and a new Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations. You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children's Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells. Job Responsibilities: Perform studies to develop genome editing strategies for human hematopoietic stem cells. Design and execute IND-enabling experiments to characterize the pharmacology of a genome-edited human hematopoietic stem cell product to treat sickle cell disease. Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays. Interact and collaborate with multidisciplinary teams to advance the program. Evaluate scale-up and close-system processes to ensure the reproducibility of the drug products. Exploratory research on developing novel in-vitro and in-vivo delivery strategies. Establish tracking and trending analyses of process development and pilot runs. Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility. Maintains regular and predictable attendance. Performs other related duties as assigned in order to meet the goals of the department and institution. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Lead Researcher Minimum Experience: Five (5) years of relevant, post-degree work experience is required Two (2) years of relevant post-degree work experience is required with a Master's degree No experience is required with a PHD Scientist Minimum Experience: Seven (7) years of relevant post-degree work experience is required Five (5) years of relevant post-degree work experience is required with a Master's degree Three (3) years of relevant post-degree work experience is required with a PhD' Senior Scientist Minimum Experience: Ten (10) years relevant post-degree work experience is required Eight (8) years of relevant post-degree work experience is required with a Master's degree Six (6) years of relevant post-degree work experience is required with a PhD Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Lead Researcher/Scientist/Senior Scientist - Yen Lab (Therapeutic Genome Engineering). Explore our exceptional benefits! Diversity, Equity and Inclusion St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. 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