Join Our Team! The laboratory of Dr. Christopher Tinkle within the Department of Radiation Oncology and Dr. Anang Shelat within the Department of Chemical Biology is seeking a highly motivated Lead or Senior Researcher interested in translating promising small molecule drug candidates into clinical trials for pediatric brain tumors. The applicant will primarily conduct rigorous preclinical in-vivo evaluation of drugs in clinical development for children using a unique collection of patient-derived orthotopic xenograft CNS tumor models and genetically engineered murine models, including such tumor types as medulloblastoma, ependymoma, and high-grade glioma. Such studies aim to inform whether a clinical trial should or should not be pursued. The applicant is expected to work alongside domain experts in the biology of pediatric brain tumors, clinicians, and pharmacologists, as well as the various institutional shared resources devoted to translational science, in a collaborative project team environment. We are seeking an ideal candidate with extensive experience in in-vivo tolerability and efficacy studies using murine models. This role requires proficiency in murine husbandry, physical observations, tissue procurement, tumor volume measurements, brain tumor xenografting, and advanced imaging techniques such as IVIS. Familiarity with various routes of drug administration and blood collection is essential, along with surgical experience and cranial implant skills. The candidate should also possess a solid understanding of preclinical therapeutic evaluation principles, including drug formulation, pharmacokinetics, pharmacodynamics, and statistical analysis of survival studies. Exceptional time management and multitasking abilities, along with strong organizational skills to adapt to evolving priorities, are crucial. Collaboration with the Brain Tumor Program's shared resources and laboratories will be a key aspect of this role. St. Jude is considered a great place to work and has been listed in Fortune magazine’s“Best Workplaces in Health Care & Biopharma™ 2020”list and GlassDoor's"BEST PLACES TO WORK 2023"list. Salary is highly competitive (comparable to industry), and employee benefits are outstanding. This position is in Memphis, TN, and relocation assistance is available. Job Responsibilities: Performs laboratory experiments using existing, modified, or newly developed techniques/protocols. Sets up protocols and troubleshoots experiments using new or modified laboratory techniques. Identifies experimental data pertinent to the analysis problem. Processes organizes, and summarizes data and reports results. May assist in the drafting and editing of manuscripts. Provides basic lab operation support, including equipment maintenance and purchasing. Monitors inventory and orders lab supplies as needed. Calibrates instruments and equipment as necessary. Provides guidance to entry-level employees. Performs other related duties as assigned in order to meet the goals of the department and institution. Maintains regular and predictable attendance. Lead Researcher Minimum Education: Bachelor's degree in a relevant scientific area is required. Minimum Experience: Five (5) years of relevant, post-degree work experience is required. Two (2) years of relevant post-degree work experience is required with a Master's degree. No experience is required with a PHD. Senior Researcher Minimum Education: Bachelor's degree in relevant scientific area is required. Minimum Experience: Two (2) years of relevant, post-degree work experience is required. No experience is required with a Master's degree. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Lead Researcher/Senior Researcher- PACT (Pediatric Accelerator of Cures for Tumors). Explore our exceptional benefits! Diversity, Equity and Inclusion St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.