The Stanford Brain Organogenesis Program within the Department of Psychiatry and Behavioral Sciences at Stanford University SchoolofMedicineisseekingahighlymotivated LifeScienceResearchProfessional2 tojoinDr.SergiuPasca’sresearchprogram in a 2-year fixed term role.

OurStanfordresearchteamseekstounderstandtherulesthatgovernthemolecularandcellularstepsunderlyingtheassemblyof the human brain and the molecular mechanisms that lead to neurodevelopmental and neurodegenerative disorders. We are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits. More specifically, we have pioneered the generation from human pluripotent stem cells of brain region-specific organoids (Nature Methods 2015; Neuron 2017; Nature Methods 2019; Nature Neuroscience 2019) and assembloids (Nature 2017; Nature Biotechnology 2020; Cell 2020), which we applied to gain mechanistic insights into disease (Nature Medicine 2018; Nature Medicine 2020).Our ultimate goal is to identify novel and reliable drug targets for neuropsychiatric disorders.

Thecandidateforthisposition willjoinanenthusiasticand multi-disciplinaryteamatStanford,and shouldideallyhaveexperience with human stem cells, neural differentiation, primary tissue culture or assay development and high-throughput screens.

FormoreinformationonthePascalabandresearchbeingperformedpleasevisittheirwebsiteatwww.pascalab.org.

Dutiesinclude:

Independentlyconductaportionoftheresearchproject(s)relatedtobuildingbrainorganoidandassembloid models. Make recommendations on experimental design and/or research direction to principal investigator.Independentlyconductexperiments(cellculture, electrophysiology)togatherdataforaportionofamajorresearchproject.Interpretandanalyzeresults,oftenwherefewguidelinesexist,andmakemodificationstoexistingproceduresand protocols.Participateinmultidisciplinaryteamsacrossdifferentfacultiesorschools.Performongoingliteraturereviewtoremaincurrentwithnewproceduresandrelatedresearch;applytoongoingresearch and development of new protocols.Contributesubstantivelytothepreparationofpapersforpublication,especiallyintheresultssection,andtopublicationof findings. Present ongoing work to colleagues and/or academic conferences.Overseesupplyandequipmentbudgetundersupervisionofprincipalinvestigatororbusinessmanager.Workwithhealthandsafetydepartmenttoensurelabcomplieswithregulationsandallrequiredtrainings.Supervise(eitherformallyorinformally)stafforstudentsasneeded,includingoversightanddirectionontechniques,as well as consultation on project work. Serve as a technical resource for other research staff.Overseethedailyactivitiesofthelaboratoryincludinglab maintenance;maintainlabstock,managechemicalinventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.

*-Otherdutiesmayalsobeassigned

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DESIREDQUALIFICATIONS:

Knowledgeandexperiencewithneurobiology,stemcellbiology,molecularbiologytechniques, electrophysiologyandcellularassays

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EDUCATION & EXPERIENCE(REQUIRED): Bachelor'sdegreeinrelatedscientificfieldandtwoyearsofrelevantwork experience; or Master’s degree or PhD in a related scientific field

KNOWLEDGE,SKILLSANDABILITIES(REQUIRED):

Comprehensiveunderstandingofscientificprinciples.Generalcomputerskillsandabilitytoquicklylearnandmastercomputerprograms,databases,andscientificapplications.Stronganalyticalskillsandexcellentjudgment.Abilitytomaintaindetailed recordsofexperimentsandoutcomes.Abilitytoworkunderdeadlineswithgeneralguidanceisessential.Excellentorganizationalskillsanddemonstratedabilitytoaccuratelycompletedetailed work. Frequently stand,walk,twist,bend,stoop,squat,grasplightly,usefinemanipulation,graspforcefully,performdesk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.Occasionallysit,kneel,crawl,reachandworkaboveshoulders,sortandfilepaperworkorparts.Rarelyclimb,scrub,sweep,mop,chopandmixoroperatehandandfootcontrols.Musthavecorrectiblevisiontoperformdutiesofthejob.Abilitytobend,squat,kneel,stand,reachaboveshoulderlevel,andmoveonhardsurfacesforuptoeighthours.Abilitytoliftheavyobjectsweighingupto50 pounds.Abilitytoworkinadusty,dirty,andodorousenvironment.Positionmayrequirerepetitivemotion.

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*-Consistentwithitsobligationsunderthelaw,theUniversitywillprovidereasonableaccommodationtoanyemployeewitha disability who requires accommodation to perform the essential functions of his or her job.

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WORKINGCONDITIONS:

Mayrequireworkingincloseproximitytobloodbornepathogens.Mayrequireworkinanenvironmentwhereanimalsareusedforteachingandresearch.Positionmayattimesrequiretheemployeeto workwithorbeinareaswherehazardousmaterialsand/orinfectious diseases are present.Employee mustperformtasksthatrequiretheuseofpersonalprotectiveequipment,suchassafetyglassesandshoes, protective clothing and gloves, and possibly a respirator.Mayrequireextendedorunusualworkhoursbasedonresearchrequirementsandbusinessneeds.

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The expected pay range for this position is $81,130 - $94,895 per annum. Stanford University provides pay ranges representing it's good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

* - Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.