Life Science Research Professional 2 (2 Year Fixed Term) **School of Medicine, Stanford, California, United States** Research Post Date Dec 12, 2024 Requisition # 105412 The Stanford Brain Organogenesis Program within the Department of Psychiatry and Behavioral Sciences at Stanford University SchoolofMedicineisseekingahighlymotivated LifeScienceResearchProfessional2 tojoinDr.SergiuPasca’sresearchprogram in a 2-year fixed term role. OurStanfordresearchteamseekstounderstandtherulesthatgovernthemolecularandcellularstepsunderlyingtheassemblyof the human brain and the molecular mechanisms that lead to neurodevelopmental and neurodegenerative disorders. We are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits. More specifically, we have pioneered the generation from human pluripotent stem cells of brain region-specific organoids ( _Nature Methods_ 2015; _Neuron_ 2017; _Nature Methods_ 2019; _Nature Neuroscience_ 2019) and assembloids ( _Nature_ 2017; _Nature Biotechnology_ 2020; _Cell_ 2020), which we applied to gain mechanistic insights into disease ( _Nature Medicine_ 2018; _Nature Medicine_ 2020).Our ultimate goal is to identify novel and reliable drug targets for neuropsychiatric disorders. Thecandidateforthisposition willjoinanenthusiasticand multi-disciplinaryteamatStanford,and shouldideallyhaveexperience with human stem cells, neural differentiation, primary tissue culture or assay development and high-throughput screens. FormoreinformationonthePascalabandresearchbeingperformedpleasevisittheirwebsiteatwww.pascalab.org. **Duties** **include:** + Independentlyconductaportionoftheresearchproject(s)relatedtobuildingbrainorganoidandassembloid models. Make recommendations on experimental design and/or research direction to principal investigator. + Independentlyconductexperiments(cellculture,electrophysiology)togatherdataforaportionofamajorresearchproject. + Interpretandanalyzeresults,oftenwherefewguidelinesexist,andmakemodificationstoexistingproceduresandprotocols. + Participateinmultidisciplinaryteamsacrossdifferentfacultiesorschools. + Performongoingliteraturereviewtoremaincurrentwithnewproceduresandrelatedresearch;applytoongoingresearch and development of new protocols. + Contributesubstantivelytothepreparationofpapersforpublication,especiallyintheresultssection,andtopublicationof findings. Present ongoing work to colleagues and/or academic conferences. + Overseesupplyandequipmentbudgetundersupervisionofprincipalinvestigatororbusinessmanager. + Workwithhealthandsafetydepartmenttoensurelabcomplieswithregulationsandallrequiredtrainings. + Supervise(eitherformallyorinformally)stafforstudentsasneeded,includingoversightanddirectionontechniques,as well as consultation on project work. Serve as a technical resource for other research staff. + Overseethedailyactivitiesofthelaboratoryincludinglab maintenance;maintainlabstock,managechemicalinventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment. _*-_ _Other_ _duties_ _may_ _also_ _be_ _assigned_ **.** DESIREDQUALIFICATIONS: Knowledgeandexperiencewithneurobiology,stemcellbiology,molecularbiologytechniques, electrophysiologyandcellularassays . EDUCATION & EXPERIENCE(REQUIRED): Bachelor'sdegreeinrelatedscientificfieldandtwoyearsofrelevantwork experience; or Master’s degree or PhD in a related scientific field KNOWLEDGE,SKILLSANDABILITIES(REQUIRED): + Comprehensiveunderstandingofscientificprinciples. + Generalcomputerskillsandabilitytoquicklylearnandmastercomputerprograms,databases,andscientificapplications. + Stronganalyticalskillsandexcellentjudgment. + Abilitytomaintaindetailed recordsofexperimentsandoutcomes. + Abilitytoworkunderdeadlineswithgeneralguidanceisessential. + Excellentorganizationalskillsanddemonstratedabilitytoaccuratelycompletedetailed work. + Frequently stand,walk,twist,bend,stoop,squat,grasplightly,usefinemanipulation,graspforcefully,performdesk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds. + Occasionallysit,kneel,crawl,reachandworkaboveshoulders,sortandfilepaperworkorparts. + Rarelyclimb,scrub,sweep,mop,chopandmixoroperatehandandfootcontrols. + Musthavecorrectiblevisiontoperformdutiesofthejob. + Abilitytobend,squat,kneel,stand,reachaboveshoulderlevel,andmoveonhardsurfacesforuptoeighthours. + Abilitytoliftheavyobjectsweighingupto50pounds. + Abilitytoworkinadusty,dirty,andodorousenvironment. + Positionmayrequirerepetitivemotion. . *- _Consistent_ _with_ _its_ _obligations_ _under_ _the_ _law,_ _the_ _University_ _will_ _provide_ _reasonable_ _accommodation_ _to_ _any_ _employee_ _with_ _a disability who requires accommodation to perform the essential functions of his or her job._ . WORKINGCONDITIONS: + Mayrequireworkingincloseproximitytobloodbornepathogens. + Mayrequireworkinanenvironmentwhereanimalsareusedforteachingandresearch. + Positionmayattimesrequiretheemployeeto workwithorbeinareaswherehazardousmaterialsand/orinfectious diseases are present. + Employee mustperformtasksthatrequiretheuseofpersonalprotectiveequipment,suchassafetyglassesandshoes, protective clothing and gloves, and possibly a respirator. + Mayrequireextendedorunusualworkhoursbasedonresearchrequirementsandbusinessneeds. . The expected pay range for this position is $81,130 - $94,895 per annum. Stanford University provides pay ranges representing it's good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs. _* - Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law._ Additional Information + **Schedule: Full-time** + **Job Code: 4952** + **Employee Status: Fixed-Term** + **Grade: G** + **Requisition ID: 105412** + **Work Arrangement : On Site**