Life Science Research Professional 3 **School of Medicine, Stanford, California, United States** Research Post Date Aug 27, 2024 Requisition # 104399 Stanford University is seeking a Life Science Research Professional 3 to perform complex functions and activities involved in defined research projects, and independently conduct a major portion of the research project(s). You will be working with an unparalleled leading-edge community of faculty and staff that are fundamentally changing the world of health care. You will have the opportunity to influence and drive change with your innovative ideas, the ability to make a difference and participate in human advancements. Our culture is fast-paced, energetic, and growing all of the time. We offer a variety of benefits beyond traditional medical, dental, retirement, and savings options: + Events and program for children, sports camps, tuition options + World-class intellectual stimulation through learning and development classes, workshops, and onsite conferences from leading-edge speakers and faculty + Work/life and family-friendly policies and reimbursement + Participation in Stanford’s social responsibility and sustainable programs for a better world + A vibrant university culture that values the uniqueness of each individual We are seeking candidates who are progressive thinkers, see challenges as simply problems to solve, and have the spirit and energy to change the world. **About the Department of Pathology:** The Department of Pathology at Stanford School of Medicine, one of its founding departments, stands as a leader among its peers nationwide. Our preeminent faculty spans from emerging leaders to highly accomplished physicians and scientists, including a Nobel laureate and members of the National Academy. Our mission is to improve the diagnosis, treatment, and basic understanding of the human disease. This is done through discovery (research), education, and clinical care. Comprised of extraordinary faculty and staff, our mission is to improve the ability to diagnose, treat and understand the origin and manifestation of human disease, and to care for those who have or are at risk to develop disease. We accomplish this through our clinical services (in all fields of anatomic and clinical pathology, including molecular and genomic pathology, histocompatibility testing and transfusion medicine) and research (which includes basic, translational and clinical research into the origins and manifestations of disease, including efforts to improve disease prediction and prevention as part of the goal of achieving precision medicine and health), and also by educating future leaders in pathology and related fields. Everything we do is to achieve the goals of providing the highest quality of clinical services to the patients for whom we passionately care, to advance our ability to understand, diagnose, monitor and ultimately to cure disease or to prevent or delay its occurrence, and to provide outstanding education and career development opportunities to those who share these goals. For more information about the department visithttp://pathology.stanford.edu/ **Lab Overview:** The Satpathy Lab studies fundamental principles of the immune system in health, infection, and cancer (Parker et al, Cell 2020; Flynn et al, Cell 2021). The lab particularly focuses on single-cell genomic and multi-omic technologies (Yost et al, Nature Medicine 2019; Rubin et al, Cell 2019) to study immunological mechanisms of disease directly in samples isolated from patients. For more information about our multidisciplinary research laboratory, seehttps://satpathylab.com/ We are recruiting a Life Science Research Professional to join a new research group within the lab focused on using gene editing and high-dimensional screening in primary human immune cells to parse the biology of cancer-immune interactions and develop new immune cell-based cancer therapies. This gene editing focused group is located at the Stanford Blood Center (3373 Hillview Ave), a short bike ride from the main campus, and is led by Dr. Theo Roth, MD, PhD. The group’s work involves synthetic re-writing of human T cell genomes using non-viral gene editing (Roth et al, Nature 2018) in high throughput arrayed and pooled genetic screens (Roth et al, Cell 2020; Blaeschke et al, Cell 2023). **About the Position:** Working as part of a multidisciplinary group, the Life Science Research Professional 3 will lead the design and construction of large libraries of DNA sequences for cellular engineering experiments, isolate and culture primary human immune cells and stem cells, and large scale pooled genetic screens. Additional major responsibilities will include next-generation sequencing library production and analysis. The LRSP will assist in grant applications, reporting, and publication of laboratory findings, as well as mentorship of technicians, trainees, and students in the laboratory. **Duties include:** + Design research approaches for a major portion of research project(s), including background research, experimental design and execution, problem-solving, and writing up for publication. + Develop new protocols; test and evaluate a variety of approaches. + Perform complex (lab and/or field) experiments and maintain detailed records of experiments and outcomes; analyze and interpret research data resulting from original procedures and methods. + Assist with new research proposals and applications for funding and grants. + Lead or participate in multidisciplinary teams across different faculties or schools. + Prepare periodic progress reports or written reports on all phases of the research project. + Contribute substantively to the preparation of papers for publication, especially in the results section. May be a co-author on publications. Present ongoing work and findings to colleagues at academic conferences. + Perform ongoing literature review to remain current with new procedures and related research; propose new research directions based on new advances discussed in literature. + Work with health and safety department to ensure lab complies with regulations and all required trainings. + Formally supervise and train new staff or students as needed, including hiring, performance management, and related duties, in addition to instruction on techniques and consultation on project work. _* - Other duties may also be assigned_ **Desired Qualifications:** + An MD (or equivalent), PhD, or BS with 7+ years of experience in independent immunology, stem cell, and/or gene editing research. + Working with and publishing on gene editing in eukaryotic cells. + Experience with primary immune cell and/or induced pluripotent stem cell culture. + Practical and applied background and expertise relevant to genetic perturbation screening. + Experience writing or reporting on research grants. + Analysis of biological data and preparation of publications. + Experience with molecular cloning procedures. + Hands-on experience operating NGS equipment. **Education & Experience (Required):** + Bachelor's degree in related scientific field and four years of relevant work experience; or Master’s degree in a related scientific field and two years relevant experience; or PhD in related science field. **Knowledge, Skills and Abilities (Required):** + Comprehensive understanding of scientific principles. + Expert level knowledge and skills in field of science related to research project. + General computer skills, experience with databases and scientific applications, and ability to quickly learn and master computer programs. + Strong analytical skills and excellent judgment. + Ability to work under deadlines with general guidance is essential. + Excellent organizational skills and demonstrated ability to complete detailed work accurately. + Developing project management skills. **Physical Requirements*:** + Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 50 pounds. + Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts. + Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls. + Must have correctible vision to perform duties of the job. + Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours. + Ability to lift heavy objects weighing up to 50 pounds. + Ability to work in a dusty, dirty, and odorous environment. + Position may require repetitive motion. _* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job._ **Working Conditions:** + May require working in close proximity to blood borne pathogens. + May require work in an environment where animals are used for teaching and research. + Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present. + Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator. + May require extended or unusual work hours based on research requirements and business needs. + Due to the nature of the work, this position will work fully on-site. **The expected pay range for this position is $93,062 to $111,670 per annum.** **Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.** **At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.** Why Stanford is for You Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with: + Freedom to grow. We offer career development programs, tuition reimbursement, or course auditing. Join a TedTalk, film screening, or listen to a renowned author or global leader speak. + A caring culture. We provide superb retirement plans, generous time-off, and family care resources. + A healthier you. Climb our rock wall or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits. + Discovery and fun. Stroll through historic sculptures, trails, and museums. + Enviable resources. Enjoy free commuter programs, ride-sharing incentives, discounts and more _The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned._ _Consistent with its obligations under the law, the university will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job._ _Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law._ Additional Information + **Schedule: Full-time** + **Job Code: 4953** + **Employee Status: Fixed-Term** + **Grade: H** + **Requisition ID: 104399** + **Work Arrangement : On Site**