Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Let’s do something amazing together! The Manager of Medical Communications will play a pivotal role in the launch of Arrowhead’s leading investigational cardiometabolic medicine, Plozasiran (siRNA targeting APOC3). The molecule has demonstrated compelling clinical data to date and is in late-stage development with the potential to treat diseases by silencing causative genes.

The Manager of Medical Communications will be a key member of Arrowhead's Medical Affairs team, reporting directly to the Director of Medical Communications. In this capacity, the responsibilities will include driving development and execution of our Medical Communications strategic plan and Medical Information roll-out and maintenance. This role will primarily play a critical part in preparation for the successful launch of Plozasiran ensuring communication deliverables are delivered on time and with excellence.

This role is based in Pasadena, California, with an expectation to be in office 5 days a week.

Responsibilities

Develop creative, innovative resources and educational content to effectively communicate scientific rationale, clinical data, protocols and other relevant information to encourage scientific exchange, ensuring compliance with industry requirements. Partner closely with field medical personnel to ensure resources meet their needs for external engagement and request fulfillment; seek regular feedback for improvements and updates. Drive Arrowhead congress participation by developing booth resources, FAQs, and training on the same. Aid in implementation of new Medical Affairs capabilities such as Medical Information. Cultivate strong cross-functional relationships, providing expert medical input as needed, and advance MedCom capabilities by collaborating with colleagues in departments including, but not limited to, Program Management, Clinical Development, Biostatistics, Regulatory, Legal, and Commercial. Execute on strategic objectives for independent medical education activities and manage external vendors for content planning and execution, as well as contractual aspects of external medical education activities, including congress symposia. Maintain execution of responsibilities within annual budget and allocation of resources, including contracts, SOWs, and accurately submitted invoices done in a timely manner. Become an expert in the current treatment landscape for the cardiometabolic platform, including Familial Chylomicronemia Syndrome, Severe Hypertriglyceridemia, Mixed Hyperlipidemia, and Familial Hypercholesterolemia. Stay up to date through horizon scanning and literature awareness, identifying and evaluating scientific gaps and opportunities to broaden data in the cardiometabolic space. Understand current state-of-the-art and new developments in RNA interference.

Requirements:

Doctorate degree (PhD, PharmD, MD) required, combined with research experience. At least three years’ experience in Medical Communications, primarily in biotech/pharma industry in cardiometabolic indications, with a clear understanding of clinical trials, drug development, regulatory, and commercialization processes. Experience in cardiometabolic therapeutic area, preferably with a focus on dyslipidemias. Demonstrated strategic thinking with innovative problem-solving and building alignment capabilities. Ability to clearly elucidate complex scientific and medical concepts via written and oral communication; detail oriented and data driven. Ability to work collaboratively in a matrixed, team-based environment, with strong organizational and time management capabilities. Exceptional project management skills, ensuring on-time and budget-compliant deliverables. Proven ability to manage compliance requirements for medical education activities. Interest in working in a fast-paced, team-based environment. California pay range $135,000—$145,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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