Platform Developer I
Cadence Design Systems, Inc.
At Cadence, we hire and develop leaders and innovators who want to make an impact on the world of technology.
OpenEye, Cadence Molecular Sciences, an industry leader in computational molecular design, uses a scientific approach to deliver rapid, robust, and scalable software, toolkits, and technology & design services for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. We are passionate about science and about taking care of our team members, with leaders supporting your development and recognizing your contributions by providing an unmatched total compensation package in a collaborative, caring, energetic and fun work environment.
Over the last eight years, OpenEye has developed the field's most advanced large-scale compute platform, Orion, built on Amazon Web Services. In this position, you will be working at the cutting edge of cloud computing to provide a platform for large-scale investigations such as advanced MD simulation techniques to investigate the mechanistic details of passive membrane permeability of drug-like molecules. Your work will have the potential to make a major impact in drug discovery research and will likely be used by many pharmaceutical and biotech companies around the world.
Orion is a container-based scientific workflow system written in Go and Python. While there are some interesting workflow and container orchestration systems out there, none deliver the flexibility in using legacy applications and toolkits, ease of use, scalability, and reliability that we are targeting. Our system is made up of Floe, a Python workflow framework, and a cloud-based workflow runtime and user interface leveraging many technologies, including Django, Docker, and AWS.
More about Orion and the science being done on it:
https://www.youtube.com/watch?v=gjKNHK4jWMQ
Below is a summary of a few of the scientific problems being solved with Orion:
Molecular Dynamics
+ Developed with Industry & Academic s/w, collaboration (OpenMM, Open Force Field)
+ Uses a combination of CPUs, GPUs (several types)
+ Relies on Elastic parallelism
Crystal Structure Prediction
+ Leverages open-source quantum mechanical code: Psi4
+ Requires iterating on science & tech. problems
+ Each iteration requires 10,000-100,000 CPU hours
+ Multiple iterations per day
The largest molecular Docking calculations ever run
+ https://docs.eyesopen.com/toolkits/python/dockingtk/docking.html
+ 43B molecules (Enamine Real, Stereo Expanded)
+ ~24 hours on 30,000 CPUs
+ 41TB result
Large Scale Virtual Screening (FastROCS)
+ Powered by OpenEye Toolkits: https://docs.eyesopen.com/toolkits/python/fastrocstk/introduction.html
+ Searches 10^11 conformers
+ Less than one-hour search, including setup and teardown of machines
+ 43B molecules (Enamine Real) searched routinely in about 30 minutes
What you should have:
+ B.S. in Computer Science or equivalent experience in addition to
+ Practical experience with algorithms used in Distributed Systems
+ Expertise working with Amazon Web Services and remote diagnostics
+ Performance-focused mindset
+ Strong Python skills - experience with package management and Django
+ Strong Golang skills - familiarity with writing servers/clients
+ PostgreSQL and SQLite - Relational database optimization and structural design
+ Comfort working with containerized systems
The following are a PLUS, but not required:
+ C+
+ + Ansible
+ flatbuffers
Benefits:OpenEye is passionate about the welfare of its employees and offers competitive benefits that include medical, dental, vision, flexible working schedule, 401k retirement plans, paid vacation, paid sick leave, home internet costs, public transportation reimbursement, and much more.
Please include a cover letter with your resume.
We’re doing work that matters. Help us solve what others can’t.
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Cadence plays a critical role in creating the technologies that modern life depends on. We are a global electronic design automation company, providing software, hardware, and intellectual property to design advanced semiconductor chips that enable our customers create revolutionary products and experiences.
Thanks to the outstanding caliber of the Cadence team and the empowering culture that we have cultivated for over 25 years, Cadence continues to be recognized by Fortune Magazine as one of the 100 Best Companies to Work For.
Our shared passion for solving the world’s toughest technical challenges, our dedication to pushing the limits of the industry, and our drive to do meaningful work differentiates the people of Cadence.
Cadence is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, basis of disability, or any other protected class.
Cadence is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, basis of disability, or any other protected class.
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