Details **Open Date** 06/30/2023 **Requisition Number** PRN35392B **Job Title** Post Doc Res Assoc **Working Title** Post Doc Res Assoc **Job Grade** A00 **FLSA Code** Administrative **Patient Sensitive Job Code?** No **Standard Hours per Week** 40 **Full Time or Part Time?** Full Time **Shift** Day **Work Schedule Summary** **VP Area** U of U Health - Academics **Department** 00244 - Neurology **Location** Campus **City** Salt Lake City, UT **Type of Recruitment** External Posting **Pay Rate Range** 50000 to 70000 **Close Date** **Open Until Filled** Yes **Job Summary** **Postdoctoral position in the Pulst Laboratory to study neurodegenerative diseases using cell and animal models** We are looking for a motivated and creative scientist to join our group as a postdoctoral research associate/fellow to study the role of the ATXN2 protein/ RNA complex in neurodegeneration, specially in TDP43-mediated diseases like ALS , FTD , and LATE (Scoles et al, Nature 2017, Paul et al, Nature Com 2018) S.) pathological conditions using human stem cell-derived organoids (Wang et al., Nature Communications 2022). We particularly welcome applications from recent or ready-to-graduatePh.D. students with backgrounds in molecular or cellular biology or from physician-scientists with a background in clinical aspects or neuropathology of neurodegenerative diseases **Responsibilities** + Conduct experiments + Draft papers and grants **Minimum Qualifications** **Preferences** Minimum qualification: PhD or MD Degree **Type** Benefited Staff **Special Instructions Summary** To apply, please send your CV and cover letter briefly describing your research interests and motivation to Dr. Pulst (Stefan.pulst@hsc.utah.edu). The following links provide more information about life in the Pulst lab: **http://healthcare.utah.edu/fad/mddetail.php?physicianID=u0595302** **http://pulstlab.genetics.utah.edu/** **Relevant publications:** Paul S et al: Staufen 1 links RNA stress granules and autophagy in model of neurodegeneration. **_Nat Commun_** 9(1):3648 (2018) Brown AS et al: MTSS1/Src family Kinase Dysregulation Underlies Multiple Inherited Ataxias. **_Proc Natl Acad Sci USA_** 115(52); E12407-E12416 (2019) Paul S et al: Staufen 1 in Human Neurodegeneration. **_Ann Neurol_** , 89(6), 1114-1128 (2021) Gandelman M et al: Staufen 1 amplifies proapoptotic activation of the unfolded protein response. **_Cell Death Differ_** . (10):2942-2951 (2020) Scoles DR et al: A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS -associated gene ATXN2. **_J Biol Chem_** , 298(8), 102228. (2022) Paul S et al: Staufen impairs autophagy in neurodegeneration. **_Ann Neurol_** . (2022) **Pulst et al:** Effects of STAU1/staufen1 on autophagy in neurodegenerative diseases. **_Autophagy._** Jan 26:1-2 (2023) **Additional Information** The University is a participating employer with Utah Retirement Systems (“URS”). Eligible new hires with prior URS service, may elect to enroll in URS if they make the election before they become eligible for retirement (usually the first day of work). Contact Human Resources at (801) 581-7447 for information. Individuals who previously retired and are receiving monthly retirement benefits from URS are subject to URS’ post-retirement rules and restrictions. Please contact Utah Retirement Systems at (801) 366-7770 or (800) 695-4877 or University Human Resource Management at (801) 581-7447 if you have questions regarding the post-retirement rules. This position may require the successful completion of a criminal background check and/or drug screen. The University of Utah values candidates who have experience working in settings with students and patients from all backgrounds and possess a strong commitment to improving access to higher education and quality healthcare for historically underrepresented students and patients. All qualified individuals are strongly encouraged to apply. Veterans’ preference is extended to qualified applicants, upon request and consistent with University policy and Utah state law. Upon request, reasonable accommodations in the application process will be provided to individuals with disabilities. The University of Utah is an Affirmative Action/Equal Opportunity employer and does not discriminate based upon race, ethnicity, color, religion, national origin, age, disability, sex, sexual orientation, gender, gender identity, gender expression, pregnancy, pregnancy-related conditions, genetic information, or protected veteran’s status. 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