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Work Shift:

8 Hours - Day Shifts (United States of America)

Scheduled Weekly Hours:

40

Union Position:

No

Department Details

The Savinov Lab focuses on studying the underlying mechanisms controlling organ-specific autoimmune diseases such as type I diabetes (T1D). Progression of T1D involves the activation of autoimmune T cells, consequent homing of activated lymphocytes to the pancreatic islets, and ensuing destruction of insulin-producing beta cells.

Pathogenesis of type I diabetes (T1D) is driven by continuous destruction of insulin-producing β cells within the pancreatic islets, performed directly by autoreactive islet-specific T lymphocytes. The Savinov Lab current research projects are focused on the mechanisms involved in the regulation of T cell activation and tolerance in regard to T1D, even though most of them could take place in other autoimmune processes. Using genetic mouse models, and variety of primary and established cell lines, we are examining the molecular mechanisms leading to inefficient negative co-stimulation, a control mechanism for T cell activation by auto-antigens, along with some defects in the intracellular signaling cascades involved in the autoimmune process.

By determining how autoimmune T cells are initially activated during T1D pathogenesis, how they home to the target organ and how they destroy their beta cell targets, causing clinical onset of T1D, the Savinov Lab hopes to find an effective molecular therapy capable of controlling the autoimmune process.
For more information visit https://research.sanfordhealth.org/researchers-and-labs/savinov-lab

Summary

Post Doctoral Fellow will perform independent scientific research including complex laboratory testing, experiments and analysis following established protocols. Designs and develops research objectives for experimentation. Analyzes and evaluates findings.

Job Description

Assists in completion of grant applications and other regulatory documents. Writes technical summaries and co-authors articles for publication. Prepares and makes formal presentations of research results.

Typically works under broad direction of principal investigator. High level of knowledge in scientific research processes, procedures, and objectives. Possesses ability to implement experiments in the subject discipline with the ability to trouble shoot issues. Good knowledge of the principles and techniques of the subject discipline required.

Teach principles and techniques of medical and laboratory procedures to junior individuals working in the lab. Possesses ability to run complex pieces of equipment requiring advanced specialized training. Possesses knowledge of modern research methods, data collection and analysis. Significant experience in analyzing and evaluating data.

General level of knowledge of project management, decision-making, and analytical skills. Strong verbal, written, and interpersonal communication skills. Ability to work collaboratively with a research group or team. Sanford Research is a multi-site institution and occasional local travel between sites may be required.

Qualifications

Requires a doctorate degree in a clinical, health, or life science field.

Management experience is highly recommended. Selected from national applicant pool or known to be nationally competitive.

Sanford is an EEO/AA Employer M/F/Disability/Vet. 

If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org.