**Job Description** **Location:** Chicago, IL **Hospital:** RUSH University Medical Center **Department:** Rush Alzheimers Dis Ctr-ResFac **Work Type:** Full Time (Total FTE between 0.9 and 1.0) **Shift:** **Shift 1** **Work Schedule:** 8 Hr (9:00:00 AM - 5:00:00 PM) **Summary:** Neuroscientist or biologist to lead effort to generate 2D and 3D Alzheimer's Disease culture models and perform a range of experiments aimed at determining druggable targets among genes and protein using human cell based validation systems. Exemplifies the Rush mission, vision and values and acts in accordance with Rush policies and procedures. Principal Duties and Responsibilities: Lead and perform range of lab-based experiments including reprogramming human somatic cells into induced pluripotent stem cells, stem cell banking and validations, stem cell differentiation into disease-relevant cell types, generating 2D and 3D culture models, phenotyping diseased cells with cellular, molecular and functional assays. Oversee the day to day organization of different components of the projects. Work collaboratively with other RADC teams who are working on related research questions. Job Requirements PhD or MD or equivalent degree in the fields of Stem Cell Biology, Developmental Neurobiology, Neuroscience, Molecular biology, Cell Biology or related fields. Excellent skills and experience in human iPSC derivation, stem cell culture and 2D/3D neural differentiation as well as directly conversion of somatic cells to neural lineages. Strong experience in designing cellular and molecular assays to phenotype "disease-in-a-dish". Experience in calcium imaging and multielectrode arrays are highly desirable. Experience in genome editing and next gene sequencing is a plus. Demonstrated skills in project planning, organization, analysis and communication. Proven ability to work independently and in collaborative team environments. The Rush University Alzheimer's Disease Center (RADC) is a leading experimental and epidemiological center for the study of Alzheimer's disease. Over the past decade, the RADC has carried out numerous community-based cohort studies and generated multi-omic data from human specimens (https://www.radc.rush.edu/). An ongoing effort is to employ a human cell-based culture system to validate AD candidate genes identified from our multi-omic data, and ultimately to bridge the gap between systems biology and drug discovery. As part of this major expansion, we are seeking a highly motivated candidate for a Postdoctoral position in Stem Cell Biology. **Position Highlights:** Our group has published in Science, Nature and Cell, and we expect that your research will be of similar high impact. To facilitate these results, you will be assisted in utilizing the most clinically detailed and extensive collection of Alzheimer's brain resources in the world. You will be supported by a faculty team of 30 statisticians, neuropathologists, systems and experimental biologists, as well as staff of 100+ who are gathering clinical and experimental detail on Alzheimer's cohorts. Examples of the rich data can be seen here and in many 1000+ citation papers. Additionally, this position offers: Priority on quickly producing high-impact publications, taking advantage of unique Alzheimer's datasets at Rush University. Thousands of post-mortem tissues available for person-specific AD models Deeply phenotyped sample origins, with multiple omics, cognitive testing and neuroimaging Sole access to the latest sequencing and cellular phenotyping equipment Pursue highly novel targets and follow effects wherever they lead Scientific focus in a flat organizational structure, with stable funding Career development and grant-writing opportunities alongside highly successful scientists The Rush University Alzheimer's Disease Center (RADC) is a leading experimental and epidemiological center for the study of Alzheimer's disease. Over the past decade, the RADC has carried out numerous community-based cohort studies and generated multi-omic data from human specimens (https://www.radc.rush.edu/). An ongoing effort is to employ a human cell-based culture system to validate AD candidate genes identified from our multi-omic data, and ultimately to bridge the gap between systems biology and drug discovery. As part of this major expansion, we are seeking a highly motivated candidate for a Postdoctoral position in Stem Cell Biology. **Company Highlights:** Ranked among the top academic medical centers in the country, Rush University Medical Center is an outstanding place to enhance your career. Everything we do centers on one goal: improving patient care. Rush University Medical Center is a five-time Magnet® facility, the highest recognition given for nursing excellence. Rush was also the first hospital in Illinois serving adults and children to receive Magnet status. Rush was ranked #1 Best Hospital in Illinois for Nurses in 2017 by Nurse.org. Leading academic medical center, acute care hospital w/ 664 licensed beds. Ranked among the top 20 "Best Places to Work" by Indeed. Rush offers a competitive salary, and valuable healthy living benefits including: health, dental and vision to help you maintain and improve your health. Rush also offers several ways to invest in your future. Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics. **Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.** **Position** Post Doctoral Research Fellow - Alzheimer Center - Stem Cell - Full-time **Location** US:IL:Chicago **Req ID** 2613