At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.
What We Do:Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie
About the Role:The postdoc in Gene Therapy vector engineering will participate in the development of novel AAV-based gene therapies and their process development. Working with our Collaboration Partners and internal colleagues in Research, CMC, and Business Development, the individual will participate in work on new and existing programs._
Your Contributions (include, but are not limited to):The primary role is to design and produce novel AAV material at various scales to advance gene therapy programs
Design and execute molecular biology and in vitro experiments in support of AAV capsid and genome engineering
Prepare data summaries and present results to peers and colleagues at Neurocrine
Be able to present data as appropriate at scientific meetings at the National and International level
Other tasks as assigned
Specific Requirements:Master's degree in biology, life sciences or related discipline, and experience in the biotech/pharmaceutical industry OR PhD or postdoc experience
Proficient in molecular biology and cell culture work
Experience with AAV production preferred, including plasmid transfection, cell material processing, and purification by ultracentrifugation
Knowledge of AAV vector design including capsid and gene regulatory elements
Backgrounds in neuroscience, protein engineering, and/or sequencing technologies are a plus
General Requirements:General knowledge of AAV biology and/or protein engineering
Experience with molecular biology techniques such as PCR, digital PCR, gel electrophoresis, western blot/ELISA, plasmid design, cloning, and sequencing
Experience with cell culture in vitro techniques such as cell passage of adherent and suspension cells, sterile technique, media preparation, cell lysis, and material processing
Experience with NGS sample preparation and data analysis
Excellent critical analysis skills and ability to assess data and research findings outside of Neurocrine for application to new scientific projects
Advanced knowledge and demonstrated ability to work with a variety of laboratory equipment/tools
Ability to work as part of teams
Excellent computer skills
Excellent communication skills
Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
#LI-DM1
Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.