Dr. Shenglin Mei lab at the Fralin Biomedical Research Institute (FBRI) Cancer Research Center- DC is seeking highly motivated Computational Biology postdoctoral associate to join our team.

The Mei Laboratory studies the remodeling and regulatory mechanisms of the tumor microenvironment during tumor progression and metastasis. The lab combines single-cell technologies, genomic datasets, machine learning, and experimental methods to investigate how the tumor microenvironment and gene regulatory factors control tumor metastasis cascade. By advancing our understanding of malignant cell heterogeneity and tumor microenvironment remodeling, we aim to drive the development of novel therapeutic approaches for patients with metastatic cancer. The current focuses in lab include the following directions: 1) Developing computational methods for integrating multi-modal data, such as scRNA-seq, scATAC-seq, spatial transcriptomics, ChIP-seq, and CRISPR screening. 2) Investigating context-dependent remodeling of the tumor microenvironment. 3) Identifying novel regulators within the tumor microenvironment. 4) Exploring tumor organ specific metastasis with multi-omics data integration.

The successful candidate will collaborate with researchers at Virginia Tech as well as have the opportunity to collaborate with colleagues at the Children’s National Hospital, including those co-located on their research and innovation campus.