Postdoctoral Associate
Job Description:Effective immediately, the Disney group in the Department of Chemistry at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (https://disney.scripps.ufl.edu) is seeking to hire a Postdoctoral Associate in RNA Chemical Biology.
Lab Overview:
The Disney group is a chemical biology laboratory focused on developing rational approaches to design highly selective therapeutics from only genome sequence. Known for its prolific output and pioneering research culture, the group has furthered advancements in annotating RNA structure from sequence alongside several novel technologies created in-house. The laboratory’s targeting of RNA by small molecules, an ambitious and highly focused enterprise in pursuit of chemical probe and lead medicine development, is summarized in Nature Reviews Drug Discovery (2023) 618(7963): 169–179.
Other representative publications from the Disney group include:
• Studying disease mediated by RNA repeat expansions that cause genetically defined ALS and dementia:
o Science Translation Medicine (2021) 13:eabd5991; doi: 10.1126/scitranslmed.abd5991
o Neuron (2014) 83:1043-50; doi: 10.1016/j.neuron.2014.07.041
o Cell Chemical Biology (2019) 26:179-190; doi: 10.1016/j.chembiol.2018.10.018
• Targeted RNA degradation and related technologies:
o Nature Reviews Drug Discovery (2023) 618(7963): 169–179; doi: 10.1038/s41586-023-06091-8
o Journal of the American Chemical Society (2021) 143:13044-13055; doi: 10.1021/jacs.1c02248
o Science Translation Medicine (2021) 13:eabd5991; doi: 10.1126/scitranslmed.abd5991
o Proceedings of the National Academy of Sciences USA (2020) 117:2406-2411; doi: 10.1073/pnas.1914286117
o Proceedings of the National Academy of Sciences USA (2019) 116:7799-7804; doi: 10.1073/pnas.1901484116
o Journal of the American Chemical Society (2018) 140:6741-6744; doi: 10.1021/jacs.8b01233
o Nature Chemical Biology (2017) 13:188-193; doi: 10.1038/nchembio.225
• Precision targeted therapeutics for difficult-to-treat cancers and other diseases:
o Journal of the American Chemical Society (2019) 141:2960-2974; doi: 10.1021/jacs.8b10558
o Cell Chemical Biology (2018) 25:1086-1094; doi: 10.1016/j.chembiol.2018.05.01
o Proceedings of the National Academy of Sciences USA (2016) 113:5898-903; doi: 10.1073/pnas.1523975113
o Proceedings of the National Academy of Sciences USA (2020) 117:1457-1467; doi: 10.1073/pnas.190505711
Our Commitment: The Disney group is highly committed to each individual’s professional development during his or her time in the lab. A high impact research project and training plan to support the achievement of short-term as well as long-term career goals is customized for each student.
Expected Salary:Commensurate with experience.
Minimum Requirements:Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry.
Preferred Qualifications:Preference will be given to candidates with strong skills in RNA biology techniques, molecular biology, and biochemical methods. Previous experience with RNA-seq data analysis, DNA encoded library design and screening, and structure-based design is also desirable.
Highly motivated candidates possessing a strong academic track-record, a high-impact publication list, a team-player mentality, and an interest in targeting the RNA world are poised for success in the group. The Disney group employs a broad range of experimental techniques, and thus a diverse set of research skills is preferable and a willingness to learn new methods is essential.
Special Instructions to Applicants:In order to be considered, applicants must upload their resume and cover letter.
Applicants should send their CV and have three letters of reference sent on their behalf directly to Prof. Matthew Disney at mdisney@ufl.edu.
Please provide names and email addresses of three to five references as part of the application process. When ready, the hiring department will contact the listed references via email requesting their reference letters to be uploaded directly to the application website.
This position is open until filled. Application review will begin March 29, 2024.
This position will be used to fill multiple postdoctoral associate openings.
This is a time-limited position.
Health Assessment Required: Yes