Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease and advancing scientific discoveries to profoundly impact human health.

The duties and responsibilities contained in the job description are intended to be examples of the accountabilities for which the person in the position will demonstrate competency through performance. The job description is not intended to be an all-inclusive list. Duties and responsibilities are subject to change and other duties may be assigned as necessary.

Summary:

Research in the Dhar lab uses a variety of biological approaches to study liver diseases, cancer and multi-organ cross-talk. Our mission is to understand how hypernutrition and metabolic stress influence the development of Metabolic associated Steatohepatitis (MASH), liver fibrosis and hepatocellular carcinoma (HCC). The overarching goal of the lab is to understand the basic mechanism of disease development in order to develop novel therapeutic approaches and biomarkers for MASH and HCC.

A Postdoctoral Associate position is available to study:

The impact of metabolic dysfunction on the initiation and progression of MASH, fibrosis and HCC. Identify novel therapeutic targets for MASH and chronic kidney disease (CKD).

Under limited direction, the Postdoctoral fellow will plan and manage all aspects of a research project including research design, experimentation, funding acquisition and publication.

Duties and Responsibilities:

Research design and planning Experimentation and trouble-shooting Data collection, analysis and interpretation Data recording and compliance Management of collaborations Results summarization Preparation of grants and manuscripts

Education and/or Experience:

Ph.D. in biomedical sciences Research background in liver and kidney diseases is preferred Experience with culturing mammalian primary and cancer cells in vitro, molecular biology techniques, lentiviral production, overexpression and knock-down or knock-out genes in vitro Using mouse models of MASH and HCC are required. Expertise in in vivo techniques such as intrasplenic injection, i.v., IP, oral gavage, sub-cutaneous injection is required Experience in harvesting and processing various mouse tissues in required. Isolation of various primary cell types from the liver in preferable Experience with immunohistochemistry and microscopy is required Ability to perform basic bioinformatics analysis of bulk or single cell RNAseq data is preferable.

Other Knowledge, Skills and/or Abilities:

Demonstrated ability to conduct and publish research projects Work independently as well as in a team environment Be responsible and have strong time management skills Able to analyze and resolve issues of high/moderate complexity Possess strong attention to detail and organizational skills Demonstrate professional communication and interpersonal skills Professional proficiency in Microsoft Office, Adobe Photoshop/Illustrator, Prism, ImageJ

Supervisory Responsibilities:

This position has no supervisory responsibilities.

Compensation:

The expected hiring range for this position is $70,000.00 to $75,000 commensurate with relevant experience.

Sanford Burnham Prebys celebrates the rich diversity of our scientists, students and staff, who hail from more than 30 countries. Our diverse and inclusive environment catalyzes innovation and fuels discovery, enhancing the value and impact of our research.

We welcome talented individuals of all backgrounds regardless of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, military or veteran status. We are proud to be an equal opportunity employer.

For additional information about your rights as an applicant, click HERE.

As part of this commitment, Sanford Burnham Prebys Medical Discovery Institute will ensure that persons with disabilities are provided reasonable accommodations for the hiring process. If a reasonable accommodation is needed, please contact our HR Partners at 858 646 3100 Ext 5127 or via e-mail at accomodations@sbpdiscovery.org.