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Job TitlePostdoctoral Fellow - Evan G. Cameron Lab

                        

LocationCleveland

                    

FacilityCleveland Clinic Main Campus

                     

Department

                      

Job CodeX1004

                     

ShiftVariable

                       

Schedule12:00am-12:00am

                       

Job SummaryHighly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

                         

Job Details

The Cameron Lab in the Department of Ophthalmic Research at the Cleveland Clinic Cole Eye Institute is seeking a highly motivated, creative, and independent scientist to study the cellular and molecular mechanisms that govern reactive astrocyte functions in the eye and optic nerve.

This fully-funded position includes the opportunity to utilize state-of-the-art multiomics approaches, rodent injury models, and human tissues to develop novel astrocyte-targeted gene therapies for glaucoma and other retinal diseases.

Candidates with a recent/expected Ph.D. should have a strong interest, background, and technical skills in several of the following: retinal and/or neurological disease, cellular and molecular biology, multiomics approaches (e.g., scRNAseq, mass spec), fluorescent microscopy, transcriptional regulation, intracellular signaling, and primary mammalian cell culture. Experience with AAV technologies and in vivo retinal disease/injury modeling is highly desired. The successful candidate will have the following responsibilities: Utilize high-throughput genomic and proteomic techniques (e.g., RNA sequencing, single-cell sequencing, spatial transcriptomics, mass spec) to identify critical genes and pathways involved in reactive astrocyte functions in the retina and optic nerve. Employ rodent ocular disease models, imaging, and behavioral assays to study the molecular, transcriptional, and functional consequences of cyclic-nucleotide signaling in reactive retinal and optic nerve astrocytes. Fluorescent and confocal microscopy of gene therapy effects in injured and diseased mouse ocular tissues. Preparation and maintenance of mouse and human primary cell cultures; purifying, characterizing and cryopreserving cells, in vitro pharmacological, expression, localization, proliferation, phosphoryaltion, and protein-protein interaction experiments.

Collaborating with team members to interpret data, generate hypotheses, and design follow-up experiments. Contributing to publishing research findings in peer-reviewed journals and presenting results at conferences and seminars.

Principal Investigator: Evan G. Cameron, PhD

Lerner Research Institute Department: Ophthalmic Research
 

Lab Research Topics:

Gene therapy developmentRetinal diseaseMolecular signalingAstrocyte-immune-neuronal interactionsReactive astrocytesFor more information about the lab’s research, please contact Dr. Cameron at cameroe7@ccf.org.

Job Responsibilities:

Independent project design with the goal of data generation, analysis, interpretation and manuscript preparationIsolate, maintain, and perform pharmacological and rDNA expression/KD experiments in primary cultured astrocytes and neuronsFixation, dissection, sectioning, and staining of retinal and optic nerve tissuesFluorescent and confocal imaging, quantitation, and analysis of stained cells and retinal tissuesPerform basic molecular biology and biochemical assays including western blots, IP, qPCR, etc.

Education:

PhD or MD/PhD requiredMD with relevant laboratory experience may substitute for PhD

Languages:

English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

Previous experience in a research or academic setting.  Graduate student experience meets this requirement.Scientific writing experience

Additional Preferred Qualities:

Experience with rodent animal handling and surgical practices (ocular is a plus but not required)Preparation of bulk and scRNAseq libraries, and/or protein samples for mass spec analysisUnderstanding or interest in astrocyte-immune, astrocyte-astrocyte,and astrocyte-neuron signaling in diseaseAAV gene therapy development experience or interest

Physical Requirements:

Ability to perform work in a stationary position for extended periodsAbility to operate a computer and other office equipmentAbility to communicate and exchange accurate informationAbility to distinguish colorManual dexterity to handle specimens and repair equipmentAbility to lift and transport equipment or specimens weighing up to 20 poundsMay be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

CVAt least 3 professional referencesEvidence of experience during graduate school (e.g. with publications and presentations) is requiredAll application materials should be submitted directly via email to Dr. Cameron at cameroe7@ccf.org.

Keywords: Postdoc, Research, LRI, Retinal Disease, Gene Therapy, Reactive Astrocytes, Glaucoma, Retinal Ganglion Cells, Optic Nerve, Animal Disease Modeling, Cole Eye Institute, Cleveland Clinic Lerner Research Institute, Translational Neuroscience, Postdoc, Cleveland Clinic, Multiomics, Mass spec, RNAseq, Behavior, Pharmacology

                       

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