**JOB DESCRIPTION** Title: Postdoctoral Fellow Salary: Department: Neuroscience Physical work location: 1425 Madison Ave, Icahn 10 th floor, room 10-52, New York NY 10029 Name PI or Supervisor: Towfique Raj, PhD; towfique.raj@mssm.edu Web link to Lab: rajlab.org Web link to Department: https://icahn.mssm.edu/about/departments-offices/neuroscience Administrative Contact: Jenny Rivera; jenny.rivera@mssm.edu Details of Research Project: The postdoctoral fellowship will support funded projects to explore the role of gene expression and RNA splicing in the diseases Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and Alzheimer's Disease (AD). The projects will combine analysis of bulk tissue and single-cell transcriptomics with both short-read and long-read RNA-seq to identify rare cellular populations and rare mRNA isoforms in the spinal cord associated with ALS, the frontal cortex in FTD, and in sorted microglia in AD and assess how these cells and isoforms associate with disease pathology, disease progression, and genetic risk factors. This work could lead to a better understanding of how glial and immune cells interact with neurons and oligodendrocytes in the nervous system, and how the neuronal response to specific protein pathologies shapes the course of disease, and could lead to new biomarkers for disease progression and therapeutic response. The candidate will have access to human patient tissues from the Target ALS postmortem tissue collection, the University College London Queen Square Brain Bank, and the Rush Alzheimer's Disease Center. The candidate will join international consortia with labs across the US and UK, and attend regular monthly virtual meetings to present progress and discuss with the other groups. The candidate will attend yearly in-person meetings funded by the Target ALS foundation to present their ALS results to a wider audience, and meet in person with the other consortium members. The candidate will join a multidisciplinary research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer's Disease within the Icahn School of Medicine at Mount Sinai. The candidate will be mentored by both Dr Jack Humphrey and Dr Towfique Raj in the Department of Neuroscience. **RESPONSIBILITIES** Technical Duties: (include any protocols) + Experience analyzing large biological datasets, including principled application of statistical techniques + Expertise in Linux and high performance or cloud (e.g., AWS or GCP) computing environments + R, Shell scripting, Python, C++, Matlab, etc. **QUALIFICATIONS** Educational and other Requirements for the position: PhD Experience Required: 1Goals/Outcomes of the Research Project: Identification of novel pathways for neurodegeneration. SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 867 - Neurosciences - ISM, Icahn School of Medicine **EOE Minorities/Women/Disabled/Veterans** The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.? **ABOUT US** **Strength Through Diversity** The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by: + Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential. + Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination. + Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers. At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally. Explore more about this opportunity and how you can help us write a new chapter in our history! **“About the Mount Sinai Health System:** Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.” **EOE Minorities/Women/Disabled/Veterans** **Requisition ID** : 3018649