**Job Description** We are looking for a Postdoctoral Fellow with a strong background in molecular and cellular biology, as well as protein biochemistry. The ideal candidate will have experience working with both cell culture and animal models. Experience in metabolism and epithelial cell biology is an advantage. The candidate should have completed their PhD within the last 1 to 1.5 years. **Appointment Term (and whether reappointment is possible):** 09/2024-09/2025 with yearly reappointment **Location of appointment:** Annenberg 18-10, Mount Sinai **Lab and department websites:** https://icahn.mssm.edu/research/domi **Wages or salary; and benefits:** $78,000 +Fringe benefits and additional UAW negotiated postdoc benefits. Lab of Dr. Prashant Rajbhandari in the Diabetes, Obesity, and Metabolism Institute (DOMI) has an opening for postdoctoral position. Rajbhandari Lab is broadly interested in 1) Immune cell regulation of lipid metabolism (Cell 2018), 2) developmental process of brown/beige and white fat, and 3) mammary gland adipose biology (Nature 2023), and 4) crosstalk between adipose and other metabolic tissues (esp liver) in the setting of obesity (Nature Medicine, Cell Metab 2017,2018). To address these topics, the lab uses cell and molecular biology, biochemistry, Next-gen sequencing (ChIP-, RNA-, ATAC-seq), animal model, single cell/nuclei RNA sequencing, and imaging. The broader significance of the work in Rajbhandari Lab is that obesity is linked to various diseases and by studying how cellular and molecular pathways are perturbed in the setting of obesity might provide better understanding of this disease. We are looking for a Postdoctoral Fellow with a strong background in molecular and cellular biology, as well as protein biochemistry. The ideal candidate will have experience working with both cell culture and animal models. Experience in metabolism and epithelial cell biology is an advantage. The candidate should have completed their PhD within the last 1 to 1.5 years. **Qualifications** Applicants must hold a Ph.D. or equivalent terminal degree in a relevant field by the start date and have research interests aligning with our department?s objectives. A complete application includes a comprehensive CV, over letter, a detailed research proposal (if required), and at least three recent letters of recommendation from academic or professional mentors highlighting the candidate's research capabilities and suitability for the role. Candidates should demonstrate a strong record of relevant research experience, evidenced by publications and proficiency in relevant methodologies and technologies. The evaluation process involves an initial screening for eligibility, a thorough review of application materials by a faculty committee, and interviews for shortlisted candidates, which may include a research presentation. The final selection considers the candidate?s fit with the department?s goals and ongoing projects, aiming to recruit individuals who show exceptional promise and dedication to advancing their field. , 021 - Metabolism Institute - ISM, Icahn School of Medicine **EOE Minorities/Women/Disabled/Veterans** The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.? **Responsibilities** **Essential Duties and Responsibilities** 1. Advanced skills in Molecular Biology techniques 2. Advanced skills in cell biology, protein biochemistry, mass-spec, immunoblotting, immunohistochemistry, mRNA in situ hybridization, confocal imaging, cell culture, etc 3. Advanced skills in Animal handing and measuring metabolic physiology in mice 4. Mammalian cell culture techniques. 5. Animal handling, colony management, and genotyping 6. Eager to learn new techniques, operate and manage lab equipment and personnel 7. Next gen sequencing, cRNA-Seq expertise is not required but preferred. + Design and conduct experiments in molecular and cellular biology, protein biochemistry, and related areas. + Work with cell culture systems to study cellular processes and protein function. + Utilize animal models to investigate biological mechanisms and validate experimental findings. + Analyze and interpret data, and present findings at lab meetings and conferences. + Collaborate with other team members to achieve research goals. + Prepare manuscripts for publication in peer-reviewed journals. **Remarks or Special Instructions** Additional Preferred Expertise and Skills (not required): Advanced skill in adipose biology. Advanced intracellular signaling pathways. Advanced flow cytometry, cell sorting Experience with adeno-, lenti-, and or AAV viral vector generation. Experience with coding languages such as R. **About Us** **Strength Through Diversity** The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by: + Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential. + Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination. + Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers. At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally. Explore more about this opportunity and how you can help us write a new chapter in our history! **“About the Mount Sinai Health System:** Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.” **EOE Minorities/Women/Disabled/Veterans** **Compensation Statement** Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.