**Job Description** Title: Postdoctoral Fellow (Req. 3019173) Salary: $73,588 Department: 866 – Department of Immunology and Immunotherapy Location: Icahn Building – 1425 Madison Avenue, 11 th Floor, New York, NY 10029 Department website: https://icahn.mssm.edu/about/departments-offices/immunology-immunotherapy Laboratory website: https://www.igen-lab.com The Sun Laboratory on Immune and Gene Engineering (IGEN) at Icahn School of Medicine at Mount Sinai is seeking highly motivated postdocs to lead projects aimed at developing immunotherapy and in vivo gene editing for treatment of inflammatory and autoimmune diseases. The research will involve exploring novel non-viral delivery technologies and new drug modalities to achieve in vivo immune modulation and immunotherapy treatments for severe diseases such as cancer, inflammatory and autoimmune diseases. This project will contribute to better understanding of the pathogenic mechanism of immune diseases, how to block or prevent the pathogenic immune process, and how modulation of the immune system results in effective treatment of the diseases. **Qualifications** Qualifications: + Ph.D. required + Experience working in a research laboratory setting This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-\_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf . **Our mission at Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.** **Mount Sinai Health System is committed to diversity and equal opportunity** SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 866 - Immunology and Immunotherapy - ISM, Icahn School of Medicine **EOE Minorities/Women/Disabled/Veterans** The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.? **Responsibilities** Technical Duties: + Immune profiling of diseases and therapeutic outcomes. + Single cell sequencing and data analysis. + Design and conduct in vivo experiments to evaluate the delivery efficiency and therapeutic impact of the new therapies. + Perform CRISPR gene editing protocols. + Conduct immunological assays, including flow cytometry, ELISA, ELISPOT, and cytokine profiling, to assess immune responses. + Perform molecular biology techniques, such as PCR, qRT-PCR, Western blotting, and sequencing, to analyze gene expression and editing outcomes. + Collaborate with team members to design and implement experiments, analyze data, and troubleshoot technical challenges. + Maintain accurate and detailed records of experiments, protocols, and results in accordance with lab standards. + Supervise and mentor junior lab members, including graduate students and technicians, as required. + Critically analyze data quality and results, and communicate findings to scientists and non-specialists. + Write or assist in writing scientific papers and grants. **About Us** **Strength Through Diversity** The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by: + Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential. + Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination. + Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers. At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally. Explore more about this opportunity and how you can help us write a new chapter in our history! **“About the Mount Sinai Health System:** Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.” **EOE Minorities/Women/Disabled/Veterans** **Compensation Statement** Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.