At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $69,000 - $179,300 **Overview:** At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. **Position Summary:** Lilly Oncology’s Large Molecule Discovery team is looking for a Principal Scientist in Chemistry/Biochemistry to support our growing biologics portfolio. This role will support Antibody-drug conjugates (ADCs) linker and payload design, develop conjugation technologies, and downstream biochemical assays to enhance ADC biological and pharmacologic properties. We are looking for a strong scientist with good knowledge and hands-on experience in designing, preparing, and characterizing ADCs. This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. He/she will be responsible for rigorous experimental design, data analysis, and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment. **Responsibilities:** + Prepare, purify, and characterize the high-quality antibody-conjugates (ADCs, ARCs, DACs etc.) with a high degree of independence in support of discovery and development of programs. + Implement state of the art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilizing novel chemistries to generate bioconjugates. + Experienced in development of purification strategies (up to 200 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration. + Experienced in ADC characterization methods, including UV-Vis, SEC, HIC, RP, IEX, cIEF, and LC-MS. + Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents. + Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences. + Engagement with multidisciplinary project teams to design, execute, and interpret experiments. + Demonstrated record of scientific accomplishments and publications. + Participate and present periodic updates and reports to management team. + Participate in long-term strategies for creation of innovative solutions and intellectual property for securing FTO for Lilly. + Maintain a safe, pleasant, and efficient working environment. **Basic Requirements** : + A minimum of a bachelor’s degree in chemistry, Biochemistry, or other related scientific discipline with a record of minimum 4 years lab-based independent research experience is required. Advanced degree (Master’s, Ph.D.) with 2+ years of relevant experience is preferred. + Deep expertise in using state-of-the-art conjugation methods and handling of highly potency cytotoxic payloads. **Additional Preferences:** + Strong hands-on experience producing and characterizing antibody and protein drug conjugates using HIC, SEC, LC-MS, IEX, and RP-HPLC. + Experience with protein purification systems is preferred with hands-on experience and proficiency working with AKTA FPLCs. + Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress. + Demonstrated ability to work well with other accomplished professionals within and across functions/teams. + Ability to multi-task and shift priorities rapidly to meet tight deadlines. + Excellent written and verbal communicator. + Detail oriented and well organized. + Enthusiastic, self-motivated, and keen to improve processes. **Additional Information:** **Physical Demands/Travel:** The physical demands of this job are consistent with a laboratory/bench environment. Some light lifting, and maneuvering may be required. _The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job._ **Work Environment:** This position’s work environment is in a laboratory/bench environment. _The_ _work_ _environment_ _characteristics_ _described_ _here_ _are_ _representative of those an employee encounters while performing the essential functions of this job._ _*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions._ Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. \#WeAreLilly