**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . The In Vivo Pharmacology team in the Cell Therapy Thematic Research Center has an opening for a highly collaborative and creative Principal Scientist with a dedication to discovery and development of novel engineered immune effector cell therapeutics for the treatment of cancer and other chronic diseases. The successful candidate will have a strong immunology background, experience with a broad range of tumor models, and a desire to lead functional workstreams from early stages/target concept through to IND filing. This position is ideal for a motivated and interactive scientist who is passionate about cell therapy and has a proven track record working across highly matrixed teams to drive key decisions for drug discovery and development. **Position Responsibilities** In the role as a Principal Scientist within the In Vivo Pharmacology Team, the ideal candidate will: + Lead functional workstreams on highly matrixed cell therapy research project teams from target concept to IND + Mentor/supervise pharmacology team members to support in vivo experimentation, including planning and directing lab research + Possess broad experience in the development and execution of tumor models, including syngeneic and xenograft models, and / or T cell-driven immune response models + Demonstrate expertise in multi-parameter flow cytometry (10-plus colors), immune cell functional assays (e.g. proliferation, cytokine production, cytotoxicity), and the field of cellular immunology + Independently author study reports, technical protocols, publications and documents to support regulatory and patent submissions, demonstrating broad experience in scientific writing + Present complex concepts to a range of audiences including governance and departmental meetings + Apply advanced technical knowledge to guide the development of cutting-edge immune cell therapies + Excel in a fast-paced team environment, meet deadlines, and prioritize work on multiple projects while fostering open and productive scientific communication and collaboration **Experience =** **Basic Qualifications:** + Bachelor's Degree + 8+ years of academic and / or industry experience Or + Master's Degree + 6+ years of academic and / or industry experience Or + Ph.D. or equivalent advanced degree in the Life Sciences + 4+ years of academic and / or industry experience **Preferred Qualifications:** + Ph.D. or equivalent advanced degree in Immunology or related field + 6+ years of academic and industry experience + Experience with preclinical assessment of therapeutic candidates including cell-based therapies, immunotherapies, and drug combination studies + Knowledge of pharmacokinetic and pharmacodynamic models to evaluate candidate therapeutics + Familiarity with gene editing technologies and delivery methods (e.g., adeno-associated viral vectors, non-viral delivery, CRISPR gene editing) + Ability to write and manage IACUC protocols, own compliance with these and other protocols, and identify potential gaps + Track record of successful internal and external scientific collaborations + Experience supervising technical staff to lead early-stage projects The starting compensation for this job is a range from $153,680 - $186,200, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. \#LI-Onsite If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. **Uniquely Interesting Work, Life-changing Careers** With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. **On-site Protocol** BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. **Company:** Bristol-Myers Squibb **Req Number:** R1589895 **Updated:** 2025-03-10 04:04:20.003 UTC **Location:** Seattle-WA Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.