**Principal Scientist, Inflammation/Immunology** **HOW MIGHT YOU DEFY IMAGINATION?** You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role. **What you will do** Let’s do this. Let’s change the world. The Department of Inflammation at AMGEN Inc. is currently seeking a dedicated senior scientist to contribute to our research efforts in developing new treatments for inflammatory and autoimmune diseases. This role requires a commitment to developing a deep understanding of the pathogenic mechanisms that underlie inflammation. In this vital role, you will be driving discovery efforts to identify how Amgen’s innovative modalities can improve the lives of patients who suffer from inflammatory and autoimmune diseases and related co-morbidities. **Key Responsibilities:** + Identification of new therapeutic targets and preclinical validation. The candidate is expected to be continuously aware of scientific developments in immunology, inflammatory diseases and the constantly evolving landscape of unmet needs in patients with inflammatory disease. + Work collaboratively with a team of expert scientists. + Present research discoveries to AMGEN colleagues and scientific meetings (oral or poster presentations and publish scientific papers in peer-reviewed journals). + Lead ethical, high-quality research experiments in accordance with regulatory agencies and compliance guidelines. + Design or assist in the development of medium to low-throughput assays used to support both small and large molecule drug development programs. + Independently design, perform, and analyze in vitro, ex vivo, in silico and in vivo laboratory experiments, including troubleshooting, optimization of assays, data collection, interpretation, biostatistical analysis, and presentation. + Participation in cross-functional drug development teams as a key intellectual and technical contributor. + Function optimally in a team-based or collaborative environment as part of a highly integrated team, possess excellent organizational, verbal, and written communication skills, and demonstrate the ability to produce reliable and reproducible results. **Win** : **What we expect of you.** We are all different, yet we all use our outstanding contributions to serve patients. The senior scientist we seek is technically adept with these qualifications. **Basic Qualifications:** + Doctorate degree and 2+ years of relevant experience OR + Master’s degree and 5+ years of relevant experience OR + Bachelor’s degree and 7+ years of relevant experience **Preferred Qualifications:** + **Research Experience:** PhD in biology with over 5 years of experience in inflammation-focused research within both academic and industry settings, experience in antibody-drug-conjugates (ADC) is highly desired. + **Scientific Contributions** : Demonstrated track record of independent scientific contributions in immunology, with a particular focus on the crosstalk between immune and stromal cells, as evidenced by publications in high-impact journals. + **Technical Expertise:** skilled in advanced research methodologies, including single-cell RNA sequencing (scRNA-Seq), multi-color flow cytometry, CRISPR/Cas9 screening, omics data analysis, complex in vitro primary cell models, cell signaling/biochemistry, in vivo mouse models for autoimmune disease, and human disease genetics. + **Collaborative Skills** : proven ability to work effectively in team environments with strong documentation, laboratory management, and communication skills **Thrive** **What you can expect of us** As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: + A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans + Flexible work models, including remote and hybrid work arrangements, where possible **Apply now** **for a career that defies imagination** Objects in your future are closer than they appear. Join us. **careers.amgen.com** In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. **Application deadline** Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.