**Position Overview:** The Process Chemistry team, part of the CMC Synthetics organization within Sanofi R&D, is responsible for the design and preliminary process development of commercial manufacturing routes for drug substances undergoing clinical development. We strongly believe that innovation is an important driver to be successful and we focus a large part of our activity on developing new synthetic routes, concepts, and technologies to provide drug substances in the most efficient, robust, economical, environmentally benign, and intrinsically safe way. We are looking for a highly motivated and collaborative individual with expertise in synthetic organic chemistry, late-stage clinical development experience to join our Process Chemistry team at the Principal Scientist level. Under the direction of Process Chemistry R&D leadership, the primary responsibility of this role is to perform and oversee multi-step route evaluation and route development activities, with the aim of establishing commercial drug substance manufacturing processes through management and execution of internal and outsourced laboratory activities. This role may oversee the activities of one or more collaborators and be responsible for their professional development. **Key Responsibilities:** + Design novel synthetic pathway for drug substances in clinical development. + Conduct and oversee route scouting in laboratory to demonstrate synthetic viability. + Use all imaginable chemistry tools and methods to establish and develop new synthetic pathways (photochemistry, biochemistry, flow chemistry, electrochemistry, on-line analysis, high throughput experimentation, structural analysis (NMR, UPLC/MS), etc.) into efficient, eco-designed and robust manufacturing processes for synthetic drug substances. + Analyze experimental data to drive synthetic experimental plans. + Assist in the design, planning and execution of multi-step experimental plans guided by risk assessment to deliver safe, efficient, robust and scalable drug substance manufacturing processes. + Investigate optimization and scale-up of reaction and purification unit operations. + Lead and collaborate within project teams by working closely with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization. + Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development report, project discussion and presentation. + Draft and review technical reports, external publications and patent applications. + May include management of outsourced laboratory activities: generating scope of work, supervising activities at CDMOs, validating reports for outsourced activities. **Basic Qualifications:** + Ph.D. in organic chemistry with a minimum of 5 years of experience within a small molecule process development organization + Demonstrated expertise in modern synthetic organic chemistry with late-stage clinical and DS process validation (PPQ) experience. + Knowledge in at least one of the following areas: advanced analytics, flow chemistry, high throughput experimentation, lab automation. + Experience in chemocatalysis or biocatalysis including characterization of catalytic processes and/or mechanistic analysis. + Strong publication record in peer-reviewed journals. + Excellent written and verbal communication skills. + Experience in the management of internal scientists and/or subcontractors. + Ability to operate with flexibility in a dynamic environment and with tight deadlines. + Strategic and innovative thinker with a track record of fresh insightful thinking by developing creative approaches to processes and practices. **Preferred Qualifications:** + Post-doctoral experience. + Proficiency with Microsoft suite + Familiarity with digital tools (e.g. Scifinder-n, Reaxys) and advanced data analysis software (e.g. Spotfire). + Design of experiment, statistical and/or thermo-kinetic modeling + Computational capabilities (e.g. molecular dynamics) and basic coding skills. + French language skills. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)