Principal Scientist (Lead), Protein Engineering

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians.  If you want to be part of this exciting work, you belong at Astellas!

 

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com.

 

Purpose and Scope:

We are seeking a talented scientist to join our efforts in discovery and engineering of novel antibodies / MicAbodies™ for the Xyphos’ convertibleCAR™ cancer cell therapy platform. This position will also support global cross-functional collaboration in antibody-based therapeutics, with the opportunity to grow as a functional leader.

 

Essential Job Responsibilities:

Execute/manage antibody discovery campaigns including antigen selection, assay development, antibody sequencing, screening, and characterization. Design maturation libraries for display platforms (affinity / potency / specificity / developability) to improve lead candidates. Design and clone/order constructs for different antibody formats including bispecific, multi-specific antibodies and antibody-fusions. Analyze and interpret experimental data, prepare clear and concise presentations to communicate results / make recommendation to project teams. Maintain detailed laboratory records, ensuring compliance with established SOPs, quality assurance measures, and regulatory guidelines. Lead or apply expertise to Astellas dug discovery programs from discovery to IND, understand the biology behind targets, integrating early research, and ensuring progression through candidate selection and nomination. Keep up with literature and scientific advancement in the biologics discovery and engineering field. Evaluate new technologies, instrumentation, and assays to implement and improve Xyphos’ protein engineering workflow.