**Join Amgen’s Mission of Serving Patients** At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. **Principal Scientist - Computational Chemistry - Amgen San Francisco** **What you will do** Let’s do this. Let’s change the world. We are actively seeking a highly qualified and motivated Principal Scientist to join the Computational Chemistry team within Amgen’s Center for Research Acceleration and Digital Innovation (CRADI). CRADI functions within our drug discovery engine to accelerate our pipeline from target inception through drug development. As part of the Computational Chemistry team, you will develop and apply tools to generate novel molecules and predict chemical properties to guide the successful discovery of small molecule therapeutics. This position is the first Computational Chemistry role in our Amgen San Fransisco site. In this vital role you will: + Participate on multiple interdisciplinary discovery project teams and play a key role in defining project strategies and achieving project milestone transitions + Apply structure-based, ligand-based and machine learning/generative design to advance drug discovery projects (both small molecule and targeted protein degradation projects) + Analyze potential drug targets to assess their druggability and help identify best modality and contribute to develop the screening strategy + Perform virtual screening campaigns to identify novel starting points + Guide and apply new Machine Learning and Artificial Intelligence technology developments + Guide and apply new protein degradation workflows working closely with Induced Proximity Platform colleagues + Contribute to guide infrastructure improvements, software portfolio recommendations and prospecting of relevant cutting-edge computational technologies/companies **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications. **Basic Qualifications:** + Ph.D. degree and 2 years of experience in computational chemistry Or + Master’s degree and 5 years of experience in computational chemistry Or + Bachelor’s degree and 7 years of experience in computational chemistry **Preferred Qualifications:** + PhD. in Computational Chemistry or related field + Proven accomplishments supporting drug design projects with 4+ years of relevant experience in the biopharmaceutical industry + Expert in the field of computational chemistry in an industry setting and good knowledge of related and adjacent disciplinary areas + Thorough understanding of the drug discovery process from lead screening to late-stage optimization and know how to maximize the impact of computational modeling + Good external publication record, excellent communication and organizational skills and demonstrated ability as a team leader **What you can expect of us** As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is $163,479 - $199,808 Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: + A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans + Flexible work models, including remote and hybrid work arrangements, where possible **Apply now** **for a career that defies imagination** Objects in your future are closer than they appear. Join us. **careers.amgen.com** In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. **Application deadline** Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.