**HOW MIGHT YOU DEFY IMAGINATION?** If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Process Development Principal Scientist – Synthetic Peptides, Oligonucleotides, ADCs **Live** **What you will do** Let’s do this. Let’s change the world. In this role Amgen is seeking Process Development Principal Scientist with industry experience in the manufacturing of synthetic peptides, oligonucleotides, and/or antibody drug conjugates to join our Drug Substance Technologies - Synthetics (DSTS) group. Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, characterization, and implementation of synthetic drug substance manufacturing processes and technologies to advance Amgen's innovative small molecule and hybrid portfolio. The Principal Scientist role will include supporting the development of efficient and sustainable manufacturing processes to prepare peptides, oligonucleotides, and/or antibody drug conjugates, driving technology innovation to support bio-conjugation, and providing technical expertise towards manufacturing and commercialization. **Key Responsibilities:** + Work with a diverse team of synthetic chemists, chemical engineers and analytical chemists to develop sustainable and cost-effective processes for synthetic peptide, oligonucleotide, and/or antibody drug conjugate manufacturing + Drive technology innovation in the synthesis, purification, and characterization of bio-conjugates + Support cGMP manufacturing and technology transfer to large-scale production facilities + Develop strategies to ensure process performance through process understanding, modeling and characterization + Guide successful completion of project deliverables and ensure timelines are met + Work cross-functionally to deliver regulatory documents and support regulatory filings + Serve as a technical expert and keep current in the field of peptide, oligonucleotide, and antibody drug conjugate manufacturing + Coach and provide career and scientific / technical advice to colleagues within the organization **Win** **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek will possess these qualifications. **Basic Qualifications:** Doctorate degree in Chemistry, Biochemistry, or Chemical Biology with 2+ years of industry experience Or Master’s degree in Chemistry, Biochemistry, or Chemical Biology and 5+ years of industry experience **Or** Bachelor’s degree and 7 years of industry experience **Preferred Qualifications:** + Experience working in pharmaceutical industry with expertise in synthetic peptide, oligonucleotide, and/or antibody drug conjugate process development and manufacturing with working knowledge of regulatory expectations + Extensive hands-on expertise in the synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates and experience with bio-conjugation techniques + Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC. + Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results + People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt + Proven track record of publications, patents and presentations **Thrive** **What you can expect of us** As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: + Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans and bi-annual company-wide shutdowns + Flexible work models, including remote work arrangements, where possible **Apply now** **for a career that defies imagination** Objects in your future are closer than they appear. Join us. **careers.amgen.com** Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.