The Department of Biological Chemistry is recruiting for a Project Scientist series position in Professor Kathrin Plath’s laboratory.

The Plath Lab at UCLA is seeking a motivated and experienced Project Scientist to join our team to advance research on in vitro stem cell-based models of early human development, specifically focusing on blastoids. Our lab uses cutting-edge stem cell biology, gene regulation, and omics techniques to study how human pluripotent stem cells can be directed to form early embryonic structures, with the goal of uncovering key molecular mechanisms that drive early developmental decisions.

Job duties and responsibilities include:

Lead and execute projects focused on the generation and characterization of human blastoids derived from pluripotent stem cells. Design and conduct experiments to dissect molecular mechanisms underlying early developmental stages and use state-of-the-art omics (genomics, metabolomics, proteomics) and imaging techniques to characterize cell populations and lineage specification within blastoids and post-implantation models. Apply genetic approaches to test functional relationships. Develop and optimize protocols for the culture and differentiation of stem cells into blastoid structures and for implantation steps. Collaborate with other lab members and external collaborators to integrate multi-disciplinary approaches in studying early human development. Mentor junior scientists, postdocs, and students in experimental design, data analysis, and scientific writing. Contribute to the preparation of manuscripts, grant proposals, and progress reports. Responsible for the maintenance of lab instruments and training new users in their operation (tissue culture equipment). Responsible for writing research papers for publication.

The qualifications for this position are as follows:

Ph.D. in Cell Biology, Developmental Biology, Stem Cell Biology, or a related field. At least 3 years of postdoctoral experience with a strong publication record. Expertise in human pluripotent stem cell culture, differentiation protocols, and organoid or stem-cell-derived embryo models. Proficiency in molecular biology techniques, including RNA-seq, ATAC-seq, CRISPR-Cas9 genome editing, and advanced imaging. Experience in bioinformatics and analyzing single cell sequencing data is highly desirable. Strong organizational, problem-solving, and communication skills. Demonstrated ability to lead independent projects and work collaboratively within a team. Background in developmental biology, especially related to early human embryonic development, is an asset.

The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. UC Nondiscrimination & Affirmative Action Policy
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Please be advised that the final candidate recommended for hire into a critical (or otherwise designated) position will be required to successfully complete a background investigation. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.

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