Job Title: Research Associate II
Job Description

Maintenance of a highly functioning in vivo and ex vivo labs, working with other members of the In Vivo Pharmacology group and other cross-functional scientists. Proficient in basic animal handling, including blood sample collection and necropsy with organ/tumor sample collection. Setup and execution of in vivo studies using xenograft mouse models of solid tumors including animal preparation/surgery, tumor implantation (s.c., i.p., i.v., or orthotopic), preparation and dosing of therapeutic T cells and other agents via various routes of administration, tracking of tumor growth (e.g., bioluminescence/fluorescence, and caliper measurements), collection of blood, tissue, tumor samples, and monitoring of animal health. Ex vivo study responsibilities include cell culture, collection, and processing of organs and tumor samples for immunological and pathological analysis. Collection, entry, analysis, and presentation of study data to project teams. Generation and maintenance of electronic lab notebook (ELN) reports, including basic statistical data analysis.

ResponsibilitiesMaintain a highly functioning in vivo and ex vivo labs.Collaborate with other members of the In Vivo Pharmacology group and other cross-functional scientists.Handle animals proficiently, including blood sample collection and necropsy with organ/tumor sample collection.Set up and execute in vivo studies using xenograft mouse models of solid tumors.Prepare and perform animal surgeries and tumor implantation (s.c., i.p., i.v., or orthotopic).Prepare and dose therapeutic T cells and other agents via various routes of administration.Track tumor growth using bioluminescence/fluorescence and caliper measurements.Collect blood, tissue, and tumor samples and monitor animal health.Perform ex vivo studies including cell culture and processing of organs and tumor samples for immunological and pathological analysis.Collect, enter, analyze, and present study data to project teams.Generate and maintain electronic lab notebook (ELN) reports, including basic statistical data analysis.Essential SkillsProficiency in in vivo studies using xenograft tumor models with immunocompromised and immune-competent mice.Experience with cell therapy and more complex experience is a plus.Proficient in sterile tissue culture techniques and working with human cells.Experience with flow cytometry assays and analysis.Proficiency in data analysis using software packages such as FlowJo, FCS Express, and Prism.Experience in data production.Additional Skills & QualificationsProficiency with mammalian cell culture techniques such as cell line passaging, cryopreservation and cell thawing, and cell counting.Proficiency in executing various xenograft tumor models using adoptive T cell transfer.Proficiency using and analyzing high-parameter flow cytometry.Work Environment

The work environment involves maintaining and operating in vivo and ex vivo labs, handling animals, performing surgeries, and conducting various assays. The role requires proficiency in using software for data analysis and maintaining electronic lab notebook (ELN) reports. It is essential to adhere to sterile techniques in tissue culture and ensure accurate data collection and analysis. The position involves collaboration with cross-functional teams and participation in various research projects.

Pay and Benefits

The pay range for this position is $35.00 - $35.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in South San Francisco,CA.

Application Deadline

This position is anticipated to close on Apr 21, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

Diversity, Equity & Inclusion

At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I are embedded into our culture through:

Hiring diverse talent Maintaining an inclusive environment through persistent self-reflection Building a culture of care, engagement, and recognition with clear outcomes Ensuring growth opportunities for our people

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.