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Job Summary

We are looking for a talented and experienced individual for a postdoctoral fellowship in a translational brain tumor research laboratory in the Department of Neurosurgery at the University of Michigan Medical School.

Using a combination of in vitro and in vivo modeling, analyses of clinical brain tumors samples and multi-omics (including single cell and spatial transcriptomics) our lab focuses on exploring the intrinsic and extrinsic tumor microenvironmental interactions mediating treatment resistance in gliomas. The projects in the laboratory will also have a strong translational component including involvement in an ongoing clinical trial.

The ideal candidate will possess extensive experience in molecular and cellular biology and will be capable of leading research projects that unravel aberrant cellular signaling mechanisms in cancer. Demonstrating the ability to work independently in the laboratory is paramount. Furthermore, as a postdoctoral fellow, you will be able to pursue innovative and exciting projects while simultaneously fostering your own independent research career.

Responsibilities*Development of targeted gene modification in cell lines, co-cultures, and mouse models to study intrinsic and extrinsic mechanisms mediating tumor progression. Develop model systems and employ novel methodologies to elucidate the underlying mechanisms of treatment resistance in brain cancerDevelopment of tools for biomarker assessment in translational brain cancer researchExhibit meticulous scientific rigor and attention to detail when designing and testing hypotheses, as well as analyzing data.  Required Qualifications*PhD in a recognized field of study related to the position with laboratory experience in cancer biology.Experience in the use of genetically engineered cell lines and mouse models.Some experience in analysis of genomic data and bioinformatics would be preferred.Have strong oral and written communication skillsHave a positive, independent, and collaborative attitude suitable for working in a research laboratoryStrong scientific curiosity and record of rigorous evidence based publications.Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Additional Information

Candidate will have an opportunity to be supported and co-mentored by a team of collaborative investigators.

References:

Al-Holou WN?Rehemtulla A. Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma. Neoplasia. 2023 Feb;36:100872. doi: 10.1016/j.neo.2022.100872. Epub 2023 Jan 6. PMID: 36621024.

Comba A, Faisal SM, Dunn PJ, Argento AE, Hollon TC, Al-Holou WN, et al. Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression. Nat Commun. 2022 Jun 24;13(1):3606. doi: 10.1038/s41467-022-31340-1. PMID: 35750880

Liu Y, ?, Rehemtulla A. Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy. Cancer Res. 2019 Jun 1;79(11):2923-2932. doi: 10.1158/0008-5472.CAN-18-2540. Epub 2019 Apr 17. PMID: 30996048;

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.