The Houston Methodist Department of Urology and the Center for Spatial Biology in GU Oncology are seeking an early-stage or mid-level investigator (equivalent to Assistant or Associate Professor level). The ideal candidate will have a strong research track record in translational cancer biology, the stromal or immune tumor microenvironment, the microbiome, or other mechanisms regulating cancer progression and therapy response. Preferred candidates will have expertise in integrating spatial profiling technologies or artificial intelligence into their study designs within the field of GU Oncology. A strong publication record and a demonstrated ability to secure extramural training or federal funding are highly desirable. The new lab will be housed in a state-of-the-art research center with easy access to cutting-edge instrumentation, including but not limited to scRNA-seq processors, spatial-omics technologies (e.g., 10X CytAssist, 10X Xenium, Akoya Phenocycler), and flow cytometry platforms such as the Cytek analyzer and sorter. The selected individual will receive substantial institutional support, including dedicated lab space, startup funds, departmental resources, and operational assistance. They will be expected to establish an independent research portfolio, secure extramural funding, and produce high-impact publications, with the ultimate goal of translating research from bench to bedside. Collaboration with translational and clinical faculty within the department and center is strongly encouraged. Interested candidates should contact the Center Director Dr. Keith Syson Chan via administrative support, Christine Nguyen, at **clnguyen@houstonmethodist.org** . **PEOPLE ESSENTIAL FUNCTIONS** + Under the direction of a Principle Investigator (PI), coordinates and provides technical direction to the work activities of research staff engaged in projects. + Performs procedures which require a highly developed technical skill. + Conducts self in a manner that is congruent with cultural diversity, equity and inclusion principles. Contributes towards improvement of department scores for employee engagement, i.e. peer-to-peer accountability. **SERVICE ESSENTIAL FUNCTIONS** + Designs, develops, or adapts equipment used in experiments or research to obtain desired results. + Establishes procedures to be applied for projects. + Participates in writing manuscripts and publications. **QUALITY/SAFETY ESSENTIAL FUNCTIONS** + Compiles, writes, and submits project results to the principle investigator. + Designs, develops, or adapts equipment used in experiments or research to obtain desired results. + Analyzes data and interprets data. + Defines problems and possible solutions as dictated by the research project. **FINANCE ESSENTIAL FUNCTIONS** + Participates in grant writing the specific grant(s). + Utilizes resources with cost effectiveness and value creation in mind. Self-motivated to independently manage time effectively and prioritize daily tasks, assisting coworkers as needed. **GROWTH/INNOVATION ESSENTIAL FUNCTIONS** + Reviews scientific literature. + Seeks opportunities to identify self-development needs and takes appropriate action. Ensures own career discussions occur with appropriate management. Completes and updates the My Development Plan on an on-going basis. This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises. **EDUCATION** + Doctorate degree in related field **WORK EXPERIENCE** + Experience in related field of study **LICENSES AND CERTIFICATIONS - REQUIRED** + N/A **KNOWLEDGE, SKILLS, AND ABILITIES** + Demonstrates the skills and competencies necessary to safely perform the assigned job, determined through on-going skills, competency assessments, and performance evaluations + Sufficient proficiency in speaking, reading, and writing the English language necessary to perform the essential functions of this job, especially with regard to activities impacting patient or employee safety or security + Ability to effectively communicate with patients, physicians, family members and co-workers in a manner consistent with a customer service focus and application of positive language principles + Demonstrated knowledge of biomedical research + Ability to work effectively in a fast-paced environment + Demonstrates flexibility and adaptability in the workplace **SUPPLEMENTAL REQUIREMENTS** **WORK ATTIRE** + Uniform No + Scrubs No + Business professional Yes + Other (department approved) Yes **ON-CALL*** _*Note that employees may be required to be on-call during emergencies (ie. DIsaster, Severe Weather Events, etc) regardless of selection below._ + On Call* No **TRAVEL**** _**Travel specifications may vary by department**_ + May require travel within the Houston Metropolitan area No + May require travel outside Houston Metropolitan area No **Company Profile:** Houston Methodist Academic Institute oversees the Education Institute and Research Institute, including 772 faculty and 56,250 learners. The Academic Institute aligns our research and education initiatives in service to the clinical mission, providing solutions that answer the call for new technologies and skills our clinicians need for patient care. Houston Methodist Education Institute coordinates our primary academic affiliation with Weill Cornell Medicine and other joint programs, including the Engineering Medicine Program at Texas A&M University Intercollegiate School of Engineering Medicine. The Education Institute also oversees continuing medical education and graduate medical education, and supports more than 1,000 trainees in residence for medical, nursing, allied health and research education programs. Houston Methodist Research Institute supports research programs and infrastructure that enable faculty across the system to bring new scientific discoveries to patients as rapidly as possible through the full cycle of a cure from conceptual bench research, to prototyping and development, to clinical trials and FDA approval. The Research Institute supports more than 1,387 clinical research protocols and $70.3 million in extramurally funded translational research programs. Houston Methodist is an Equal Opportunity Employer. Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law. VEVRAA Federal Contractor – priority referral Protected Veterans requested.