This is what you will do:

This role requires a motivated, creative scientist with experience in nephrology to join our Exploratory Biology team and drive new target discovery and preclinical research programs in rare kidney diseases. You will identify and validate new targets using cellular and molecular biology approaches and contribute to development of new therapies using modalities including small molecules, biologics as well as gene therapy.  Your responsibilities will include building cellular-based disease model systems to elucidate key mechanisms used in the testing and optimization of therapeutic modalities. You will collaborate with functions in Alexion and AstraZeneca to leverage internal capabilities to identify the best therapeutic options for our patients.

You will be responsible for:

Identifying new targets in rare kidney disease through knowledge based, bioinformatic or phenotypic methodsEstablishing “state of the art” cellular models of kidney disease that will allow for understanding key biological mechanisms and support novel therapeutic discovery programsEstablishing strategy for new target research efforts in Exploratory BiologyBringing forward proposals for new research programs in rare renal diseaseLeading preclinical projects in rare kidney diseases by management of creative, hypothesis-driven, scientific research to identify treatments for patients suffering from rare diseasesLeading external collaborations to identify new target ideas and technologies

You will need to have:

PhD with postdoctoral experience and 4+ years of experienceMS or BA/BS in relevant field of study and 12+ years of experienceIn depth knowledge of kidney physiology and mechanisms of renal diseaseExperience in the development and analysis of relevant renal cell-based platformsAbility to lead multi-disciplinary scientific projectsExcellent oral and written communication skills

We would prefer for you to have:

Practical experience in a pharmaceutical research setting with a proven track record of scientific innovationExpérience in leading and mentoring associate scientists

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.