Position Title:  Research Scientist/Senior Scientist, Peptide Chemistry

ABOUT US 

Calibr, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities.  Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr’s drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.

Position Summary: 

We are seeking an experienced and highly skilled Peptide Chemist to join our dynamic team in San Diego. The ideal candidate will possess exceptional academic credentials in peptide and chemistry, as well as expertise in bioconjugation and knowledge in chemical biology.

In this role, the successful applicant will be a key member within the laboratory and make significant contributions to the advancement of Calibr's peptide drug discovery portfolio. Primarily, the candidate will be responsible for the design and synthesis of analogs intended to enhance the potency, pharmacokinetics, safety, and in vivo efficacy of potential drug candidates.

Furthermore, the candidate will enjoy ample opportunities to learn and actively participate in multidisciplinary drug discovery projects, making a meaningful impact and engaging in independent ideation to drive innovative practices. Ultimately, this role will play a crucial part in accelerating peptide drug discovery endeavors at Calibr.

The position presents an excellent opportunity for career growth and to work in an environment with cutting-edge technology and a culture that embraces collaboration, engagement, and development.

Responsibilities:

Play a leadership role in our peptide drug discovery and development efforts, contributing to the advancement of long-acting peptides and peptide-protein conjugates into effective clinical candidates. Participates in a multidisciplinary team committed to the expeditious identification of development compounds and advance discovery projects through critical preclinical stage gates.

Key Requirements:

D and/or postdoc in chemical or biological sciences with a strong focus on peptide chemistry. 1-4 years of experience in academia or a biotechnology/pharmaceutical company. Master’s degree with a minimum of 5 years of relevant experience in industry or Bachelor's degree with 10+ years of experience. Skilled in contemporary peptide synthesis techniques, protein bioconjugation, and the analytical characterization of peptides and proteins.

Additional Preferences:

Strong understanding of peptide and protein structure and associated biophysical techniques to assess structure, stability and behavior in solution. Experience in bioconjugation, time-extension and formulation strategies for peptides and proteins. Review research papers and intellectual property literature in support of SAR of peptide drug design and/or delivery. Demonstrated ability to work independently as well as in cross-functional team Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency Self-motivated, strong work ethic, independent and results oriented.

Physical Requirements:

This position works in a laboratory environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

COMPENSATION

The expected hiring range for this position is $108,000.00 to $129,600.00 commensurate with experience. Consideration will be given to experience that exceeds the listed requirements.

COMPREHENSIVE BENEFITS INCLUDE

Employer Contributed Retirement Plan – Depending on eligibility, employees receive an employer contributed retirement plan (no employee contribution required) and the option to contribute to a 403(b) (which is similar to a 401(k) using your own pre or post-tax dollars) Full Suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more Access to Flexible Spending Accounts (Medical/Dependent Care) Competitive vacation and sick leave policies Free, on-site parking

The above statements describe the level of work performed and expected in general terms.  The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice.   Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff. 

EEO Statement:
The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Underrepresented individuals are encouraged to apply.