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DescriptionDr. Kathryn Oliver is currently seeking a Research Specialist to join her team in the Department of Pediatrics at the Emory University School of Medicine. Dr. Oliver’s research program broadly investigates ways in which ribosome function and mRNA surveillance impact aberrant protein synthesis in the context of inherited conditions such as cystic fibrosis (CF). Current studies address feasibility of ribosomal suppression as a novel therapeutic strategy for overcoming refractory defects in the CF transmembrane conductance regulator (CFTR) – with particular emphasis on premature termination codons and other rare variants. This includes mechanistic evaluation of global and transcript-specific effects on ribosome fidelity and speed, in addition to biochemical assessments of CFTR protein biogenesis and activity. Research projects are highly innovative and translational, incorporating use of human- and murine-derived materials.
KEY RESPONSIBILITIES:
Under general supervision, performs a variety of defined research and laboratory tests and experiments according to prescribed protocols and assigned schedules.Sets up experiments as prescribed by a principal investigator.May be required to participate in laboratory maintenance activities such as sterilization and cleaning of equipment, ordering of supplies, inventory and media preparation.Maintains records, files and logs of work performed in laboratory notebooks and computer databases.Compiles data and records results of studies for publications, grants and seminar presentations.Employees in this classification may be required to work with, take specific precautions against and/or be immunized against potentially hazardous agents.Performs related responsibilities as required by principal investigator.ADDITIONAL JOB DETAILS:
Activities routinely performed in the laboratory include:
Molecular biology techniques such as DNA/RNA isolation and purification; PCR amplification; qRT-PCR; gel electrophoresis; and preparation of sequencing libraries.
Biochemical protocols including but not limited to cytotoxicity and cell migration assays; protein quantification and visualization (e.g. western blot, protein half-life, immunoprecipitation); cell surface detection of HRP-tagged polypeptides; mRNA stability assays; sucrose gradient fractionation; ribosome run-off assays; and electrophysiology (short-circuit current analyses).
Processing human clinical specimens (e.g. respiratory epithelia) from CF and non-CF patients, as well as a variety of mouse tissues.
Experience with protein biochemistry assays.
Educational background in genetics, genomics, and/or bioinformatics.
Eager to broaden scientific knowledge and develop new technical skills.
Thorough and timely note-taking abilities.
Detail-oriented, inquisitive, and communicative disposition.
Perform tasks with utmost integrity.
Embrace working collegially with individuals from diverse backgrounds (e.g. gender, race, ethnicity, LGBTQ+, physical ability, socioeconomic status, geographic origin, etc).
MINIMUM QUALIFICATIONS:
Bachelor's degree in a scientific field OR equivalent combination of experience, education, and training.NOTE: Position tasks are generally required to be performed in-person at an Emory University location. Remote work from home day options may be granted at department discretion. Emory reserves the right to change remote work status with notice to employee.
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