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At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community.  We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.

At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare — people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds – to apply.

 

 

Job Summary

The Research Technician I will perform standard laboratory procedures in the laboratory of Dr Marneros at the Cutaneous Biology Research Center/MGH.

Duties include: Mouse colony management and husbandry including Tag and tail, genotyping, and euthanasia and tissue harvest, as well as phenotypic characterization of mouse phenotypes. Other responsibilities will include routine molecular biology, histology/immunochemistry, microscopy and flow cytometry in support of projects in cutaneous biology and immunology.

Our laboratory is investigating molecular mechanisms involved in wound healing, angiogenesis and inflammation.

 

Qualifications

Our laboratory is investigating molecular mechanisms involved in wound healing, angiogenesis and inflammation.

Wet Lab Experience RequiredPlease submit your Unofficial TranscriptSubmit Letters of Recommendation

Project 1: We investigate the role of proangiogenic factors for wound healing and age-related diseases. We could show that the proangiogenic factor VEGF-A induces oxidative stress and NLRP3 inflammasome activation to promote age-related diseases (Cell Reports, 2013; FASEB J, 2014; EMBO Mol Med, 2016; FASEB J, 2018, eLife, 2020). We use a variety of in vivo and in vitro approaches to investigate a novel pathogenic link between VEGF-A and NLRP3 inflammasome activation.

Project 2: We identified a novel pathway that is critical for epithelial differentiation, especially in the kidney and skin. This new pathway plays a critical role in kidney and skin development (Dev Cell, 2020; Cell Reports, 2021; J Clin Invbest, 2024). We are exploring key novel molecular mechanisms that regulate skin and kidney development, with implications for several skin and kidney diseases.

In summary, our laboratory uses a large number of diverse experimental approaches (human genetics, mouse genetics, chemical screens, in vitro assays, cutting-edge imaging technology) to define novel mechanisms in angiogenesis, wound healing and inflammation. All of our projects have strong translational clinical relevance.

Our laboratory is embedded in a highly productive and well-equipped environment at the Cutaneous Biology Research Center of Massachusetts General Hospital/Harvard Medical School. Cutting-edge technologies are available within our Department and the MGH/Harvard research community.

lab website: https://www.massgeneral.org/dermatology/research/cutaneous-biology-research-center/faculty-labs/alexander-marneros-lab

Interested candidates should send the CV and references to Alexander G. Marneros, M.D., Ph.D.,

Email: amarneros@mgh.harvard.edu

Principal Duties and Responsibililtes

Prepares basic solutions and performs base-level procedures as assigned (i.e. Pipetting, cell and tissue culture, molecular biology and biochemistry procedure etc).There will be routine maintenance work for supporting the laboratory such as general laboratory.Perform routine assays, including RT-PCR, western blots, tissue processing, stainings and immunolabelingConduct analysis of resultsWill assist in procedures with rodent modelsMaintain a laboratory notebookAttend weekly laboratory meetings and maintains laboratory notebooks.Will perform other duties as assigned

Skills/Abilites

Must exhibit initiative and is able to work independently when trained.Must have technical ability, proficient, and accurate in scientific experimentation.Ability to work in a group environment and be of assistance to a number of research projects.Excellent written and verbal communication skills

Education

Bachelor of Science/Art required

Experience

Prior laboratory experience preferred, especially in working with mice.

 

Additional Job Details (if applicable)

 

Remote Type

Onsite

 

Work Location

149 Thirteenth Street Building 149

 

Scheduled Weekly Hours

40

 

Employee Type

Regular

 

Work Shift

Day (United States of America)

 

EEO Statement:

The General Hospital Corporation is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

 

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