Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. **Scientific Associate Director - PKDM (Small Molecule Modeling and Simulation)** **What you will do** Let’s do this. Let’s change the world. In this vital role you will characterize the absorption, distribution, metabolism, excretion and pharmacokinetic (ADME) properties of small molecule drug candidates to achieve their full pharmacological potential. In this role, your core responsibilities include leading strategically and scientifically a team of pre-clinical PKPD and PBPK modelers responsible for: + Planning and execution of mechanistic PKPD analyses to integrate knowledge of drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics, and to optimize compound properties, dose-selection and preclinical study designs + Working closely with discovery scientists (biologists, translational scientists, medicinal chemists, biochemists, pharmacologists, toxicologists) to codify their knowledge and discover new insights using advanced PKPD modeling techniques + Characterizing drug-target interactions by pharmacologically and toxicologically. This includes but is not limited to characterizing the risk for drug-drug interactions + Contributing to the analysis of pre-clinical PKPD data for IND and NDA filings, and documentation in appropriate reports. + Work closely with business development group to evaluate external opportunities + Build close relationships with partner functions and therapeutic areas in addition to leading the quantitative pharmacology team + Responsible for ensuring robust translation understanding of PK and PD from pre-clinical to clinical through partnership between PKDM, the Clinical Pharmacology & Modeling and Simulation, and Precision Medicine teams + Contribute to developing and driving strategy within PKDM and growing visibility & impact cross-functionally **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek will possess these qualifications. **Basic Qualifications:** + Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 4 years of relevant experience OR + Master’s degree and 7 years of relevant experience OR + Bachelor’s degree and 9 years of relevant experience **Preferred Qualifications:** + PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training. + Expertise in computational and mechanistic PK/PD, PBPK and translational modeling + Experience in supporting preclinical/clinical PK, PK/PD, and modeling & simulation components of regulatory documentations. + Excellent interpersonal, technical, and communication skills to lead cross-functional teams + Past experience as a laboratory scientist and in a biotech environment + Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills + Record of scientific contributions through peer-reviewed articles and external presentations + Strong background in integrating preclinical data sets to aid in the development of translational PK/PD models for small molecules. + Proven technical expertise in quantitative pharmacology and strong hands-on modeling and simulation experience with Pheonix WinNonlin, R, SimBiology, SimCYP, GastroPlus and/or other modeling and simulation software and data visualization tools. + Experience in managing and mentoring modelers and scientists + Ability to drive the progression of discovery and development project teams **What you can expect of us** As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: + A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans + Flexible work models, including remote and hybrid work arrangements, where possible **Apply now for a career that defies imagination** Objects in your future are closer than they appear. Join us. **careers.amgen.com** In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.