Job Title: Scientist, Biologics Characterization-Mass Spectrometry

Location: Framingham, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

The BioAnalytics Department in Sanofi Global CMC Development is seeking a highly motivated scientist to join the Characterization group. The successful candidate will utilize advanced bioanalytical tools with a focus on mass spectrometry and chromatography-based techniques to characterize a variety of biotherapeutics at all stages of development to enable critical decision-making and ensure the successful development of new drugs.  

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities

Identify sequence liabilities in therapeutic proteins to assist pre-candidate selection as part of developability assessments.

Perform detailed structural characterization including protein sequence confirmation, sequence variant identification, qualitative and quantitative analysis of post-translational modifications (e.g. glycosylation and disulfide bonds) in support of IND enabling studies, forced degradation and comparability studies.

Collaborate with group members and cross functional teams to conduct stress studies and support structure-function studies, process development, and formulation studies.

Evaluate and develop new technologies to improve the quality and efficiency of the characterization workflows and to solve problems encountered during drug development.

Author study protocols, technical reports, and manuscripts for publication; present at internal and external seminars and conferences.

About You

Basic Qualifications:

PhD in Chemistry, Biology, or a related discipline, or a Master's degree in relevant discipline with > 4 years of relevant experience

Strong technical background and expertise in protein mass spectrometry including LC-MS intact protein analysis, peptide mapping, and PTM characterization

Demonstrated ability to work independently and as member of a team while adhering to timelines

Self-motivated, detail-oriented, strong problem-solving and communication skills

Preferred Qualifications:

Hands-on experience in analytical separation methods, biophysical characterization techniques, and high throughput automation platforms 

Experience in scientific programing and scripting

Experience in glycoprotein and antibody characterization

Why Choose Us?

Bring the miracles of science to life alongside a supportive, future-focused team.

Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!

US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.