Site Name: Cambridge Binney Street Posted Date: Feb 3 2025 We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated. We are currently seeking a highly motivated scientist with hands-on experience in organic synthesis (preferably in the polysaccharide chemistry area) to join our protein science team. Prior experience of working in the conjugate vaccine development projects will be plus. Our protein science team is responsible for generating high quality protein and polysaccharide antigens from different bacterial pathogens to support our vaccine development programs. You will work closely with the members from immunology and molecular biology groups in a highly collaborative environment. Key Responsibilities: Independently purify polysaccharides, develop and optimize protocols for chemical modifications of bacterial capsular polysaccharides to enable generating protein-polysaccharide complexes as conjugate vaccine candidates. Characterize purity and homogeneity of the purified polysaccharides and protein-polysaccharide complexes using various analytical and biophysical tools e.g. RP-HPLC, SEC-HPLC, SEC-MALS, DLS, NMR, spectrophotometric assays etc. Independently troubleshoot challenges and come up with novel solutions. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Ph.D. with 0+, MS with 2+ or BS with 5+ years of hands experience in Synthetic Organic Chemistry, Chemical Biology or process sciences in a pharmaceutical/biotech industry. Prior experience in organic/carbohydrate synthesis and the understanding of reaction mechanism is needed. Knowledge of analytical and bio-physical protein characterization techniques like: RP-HPLC, SEC-MALS, NMR, DLS, etc. Preferred Qualifications: If you have the following characteristics, it would be a plus: Strong ability to multi-tasking and willingness to work effectively in a highly collaborative and diverse environment as a team player with a strong work ethic. Able to maintain written records in the form of laboratory notebooks. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. 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