Adecco Healthcare & Life Sciences is hiring a contract Scientist for our Pharmaceutical partner in Cambridge, MA. The anticipated hourly wage for this position is between $56 and $57.60. Hourly wage may depend upon experience, education, geographic location, and other factors. Benefit offerings include medical, dental, vision, life insurance, short-term disability, additional voluntary benefits, EAP program, commuter benefits and 401K plan. Our program provides employees the flexibility to choose the type of coverage that meets their individual needs. Available paid leave may include Paid Sick Leave, where required by law; any other paid leave required by Federal, State, or local law; and Holiday pay upon meeting eligibility criteria **Job Summary:** Scientist I or Scientist II to join the Non-Viral Gene Therapy (NVGT) Team. The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry. The candidate will work closely with the LNP formulation team to achieve extrahepatic delivery of LNPs. **Responsibilities:** · Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues. · Perform downstream analytical assays such as SDS-PAGE, SEC-HPLC, RP-HPLC, BLI, DSF, CE-SDS and/or flow-cytometry. · Perform incorporation of targeting antibody into LNPs and execute associated analytical assays, including DLS, zeta potential, nucleic acid content, endotoxin · Design protein and antibody molecules at the primary sequence level · Support management of CRO for molecule production · Closely work with therapeutic area biologists and project teams to design functional experiments and interpret data · Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members. · Plan, execute, and record experiments as guided in a time sensitive manner. · Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory. · Author standard operating procedures, study plans and reports and present findings. · Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture. **Requirements:** · PhD in Chemistry, Biology, Biological Engineering, or a related field with a minimum of 1-3 years of relevant industry experience. · Strong experience with protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization · Direct experience with site-specific bioconjugate chemistry · Strong analytical biochemistry experience for protein and antibody engineering · Proficient in performing structure-function analysis and bioinformatic analysis of antibodies, antigens, and other proteins · Experience with automation and high throughput platform(s) · Experience with Biolayer Interferometry or equivalent technique · Preferred use of computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience · Preferred familiarity with formulation and analysis of lipid nanoparticles for research use · Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting. · Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn. · Demonstrated ability to independently design, execute, interpret, and present experimental results. · Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment. **Must Have:** · PhD in Chemistry, Biology, Biological Engineering, or a related field · 1 year of professional work experience (in biotech or pharma) · Protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization. · Bioconjugate chemistry, also referred to as: antibody conjugate experience ADJ · Strong analytical bio chem skills · SDS page, chromatography, HPLC **Preferred Skills:** · Previous experience with: (liquid handler, automated buffers) – biochemical assays (nice to have) · Computational skills · Computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience. · L&P Experience **Pay Details:** $56.00 to $57.60 per hour Benefit offerings available for our associates include medical, dental, vision, life insurance, short-term disability, additional voluntary benefits, EAP program, commuter benefits and a 401K plan. Our benefit offerings provide employees the flexibility to choose the type of coverage that meets their individual needs. In addition, our associates may be eligible for paid leave including Paid Sick Leave or any other paid leave required by Federal, State, or local law, as well as Holiday pay where applicable. Equal Opportunity Employer/Veterans/Disabled To read our Candidate Privacy Information Statement, which explains how we will use your information, please navigate to https://www.adecco.com/en-us/candidate-privacy The Company will consider qualified applicants with arrest and conviction records in accordance with federal, state, and local laws and/or security clearance requirements, including, as applicable: + The California Fair Chance Act + Los Angeles City Fair Chance Ordinance + Los Angeles County Fair Chance Ordinance for Employers + San Francisco Fair Chance Ordinance