Worcester, MA, 01613, USA
19 days ago
Scientist II, AAV Purification
Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok (https://www.tiktok.com/@abbvie) . Job Description The Genetic Medicine and External Partnerships (GMEP) Group is seeking a highly motivated and experienced Scientist to join our AAV Technologies team and work collaboratively with our therapeutic area teams to advance AbbVie’s rAAV pipeline. The successful candidate will have experience in protein chromatography and analytics. The candidate will work in a fast-paced environment to investigate, develop, and optimize methods and technologies through hands-on laboratory work and literature review. Key Responsibilities Include: + Purification of rAAV to support discovery research + Develop and optimize production of high concentration and high quality AAV preps + Perform AAV analytical assays to support AAV analytical team. + Analyze experimental data, generate plots, and summarize results and conclusions. + Maintain a comprehensive Electronic Lab Notebook documenting experiments. + Independently design, execute, and interpret critical experiments to answer scientific questions + Understand the broad objectives of the project as well as their role in achieving those objectives, and modify experimental plan when required, to respond. + Innovate and implement new experimental protocols. + Demonstrate a high level of proficiency. + Set and meet experimental timelines. Impact projects mostly through lab activities. + Learn, understand, and master new experimental techniques, and act as a resource of mentor for others. + Routinely read and apply relevant scientific literature. Contribute to writing and conceptual framework of publications, presentations, and patents. Effectively organize and present scientific plans and data. + Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials in a BSL2 environment. Qualifications + BS or equivalent education with typically 7 or more years of experience, or MS or equivalent education with typically 5 or more years of experience, or PhD and no experience necessary + Experience with AKTA FPLC systems and chromatography methods + Experience with analytics i.e., ELISA, SDS-PAGE, CE-SDS (WES/JES) + Demonstrated ability to learn, understand, and master new experimental techniques. + Ability to multitask and work within timelines. + Demonstrated scientific writing skills and strong verbal communication skills. Preferred Qualifications: + Immuno Affinity Purification of multiple rAAV serotypes + Empty/Full Capsid Separation via ion exchange chromatography and ultracentrifugation + Background in viral vector analytics + Experience with characterization of rAAV or other viral vectors (e.g. lentivirus, Adenovirus) Key AbbVie Competencies: + Builds strong relationships with peers and cross functionality with partners outside of the team to enable high performance. + Learns fast, grasps the “essence”, and can change course quickly where indicated. + Raises the bar and is never satisfied with the status quo. + Creates a learning environment, open to suggestions and experimentation for improvement. + Embraces the ideas of others and nurtures innovation to make possibilities real. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ + The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​ + We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​ + This job is eligible to participate in our short-term incentive programs. ​ ​ Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html Salary: $80,500 - $153,000
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